Construction of preventive approaches in pediatric dentistry field for inflammatory bowel diseases caused by oral bacteri

变形链球菌是龋齿的主要病原体，已知其侵入血液并且有时引起全身性疾病。本研究探讨了沙门氏菌致炎症性肠病加重的可能机制。变异人我们发现肝细胞被S.变形杆菌产生IFN-γ，而α-AGP和淀粉样蛋白A1增强炎症并使免疫系统失衡，导致炎症性肠病恶化。此外，还显示了针对IFN-γ的中和抗体改善了病症。

Streptococcus mutans, a major pathogen of dental caries, is known to invade the bloodstream and sometimes causes systemic diseases. The present study investigated the possible mechanism of aggravation of inflammatory bowel diseases caused by S. mutans. We found that hepatocytes invaded by S. mutans produced IFN-gamma, while alpha-AGP and amyloid A1 enhanced inflammation and unbalanced the immune system, leading to aggravation of inflammatory bowel diseases. In addition, it was shown that the neutralizing antibody against IFN-gamma improved the condition.