Age-related changes in peripheral circulatory function and in serum condition childhood and their relation to life styles

本研究通过日本学生进行横向研究，以确定外周循环功能的变化，并明确血清状况的变化。当我们分析青少年加速体积脉搏波（APG）波形时，我们必须排除身高增加导致体形增长的影响。在本项目中，我们采用标准的高度-d/a曲线来评价APG指数d/a，以排除高度增加的影响。因此，我们能够澄清d/a与动脉硬化可变危险因素的关系。因此，标准的身高-d/a曲线是通过APG评价处于生长期的青少年外周循环功能的有用工具。对315名健康儿童（170名女孩和145名男孩）进行了横向研究，平均年龄为13.6岁，分别就读于小学、初中和高中。我们用血压计测量血压（BP），并测量BMI、血浆NE、INS和LEP。6例肥胖，LEP为16.6±13.3 ng/ml。INS为16.2±7.5 μ/ml，总能量消耗为2450±330 kcal，显著高于正常对照组（p<0.001）。高血压患者9例，体重维持到12岁。男孩的LEP水平总是低于女孩。LEP与BMI（r=0.38, p<0.001）、舒张压（r=0.14, p=0.009）、INS（r=0.19, p<0.001）呈正相关。逐步logistic回归显示MI（t=8.95）、DBP（t=2.71）和INS（t=2.33）与LEP有显著相关。这些数据表明，1)肥胖儿童仅占3.5%，其瘦素、胰岛素和消耗能量极高；2)瘦素与BMI和DBF有显著相关性。

This study was transversally undertaken to determine the changes of peripheral circulatory function and to clarity the changes of serum conditions through the use of Japanese students.When we analyze wave forms of accelerated plethysmography (APG) in adolescent, we have to exclude effects of increasing height resulting form growth. In this project, we evaluated the index of APG, d/a, with using the standard height-d/a curves, in order to exclude the effects of increasing height. We were, then, able to clarify the relation of d/a to variable risk factors of arthevosclerosis. Consequently, the standard height-d/a curves are useful tools for evaluating the preripheral circulatory function in adolescent, who are in growing stage, by the APG. 315 healthy children (170 girls and 145 boys), mean age, 13.6 years, in elementary, junior high and high school, were transversally studied. We performed blood pressure(BP) measurements by a sphygmomanometer and measured BMI, plasma NE, INS and LEP. Obesity was found ll subjects whose LEP were 16.6±13.3 ng/ml. INS were 16.2±7.5 μ/ml and total energy consumption were 2450±330 kcal. These were significantly higher than normal controls(p<0.001). Hypertensives were9 subjects and with body weight until 12 years. Boys always had lower LEP levels than girls. There was appositive correlation between LEP and BMI(r=0.38, p<0.001), diastolic(D)BP(r=0.14, p=0.009), INS(r=0.19, p<0.001). Stepwise logistic regression showed that MI(t=8.95), DBP(t=2.71)and INS(t=2.33)were significant correlation with LEP. These data suggest that in the children 1)obesity were found only 3.5%, whose leptin, insulin and consumption energy were extremely high and 2)leptin have a significant correlation with BMI and DBF.