Physicochemical and molecularbiological modification of artificial joint surfaces used the compromised patients

人工全关节置换术患者术后并发症发生率较高。可以推测，表面自由能的降低会降低人工关节表面的摩擦系数和对细菌的吸附。氟烷基化是一种降低表面自由能的表面改性方法，用于全置换关节表面的生物材料的改性可能由于降低表面自由能而降低摩擦系数和对细菌的吸附。本研究的目的是验证这一假设，评价改性超高相对分子质量聚乙烯(UHMWPE)和多晶氧化铝陶瓷(PCAC)的碳纤维。证实了生物材料表面自由能的降低和氟烷基化。用机械光谱仪测量UHMWPE和PCAC(对照或改进)之间的cf，使用圆盘-圆盘几何形状随角速度变化。在250千帕的压力下对圆盘施加垂直载荷。在所有的角速度范围内，改性PCAC对UHMWPE的CF值都有明显的降低。氟烷基化是一种简单的表面改性方法，它能在很薄的一层中聚合材料表面的氟烷基。生物材料的氟烷基化有可能在临床上用于解决全关节置换术后的并发症。

Total joint replacement for the compromised patients has the higher ratio of complication. It can be speculated that the reduction of surface free energy would decrease friction coefficient of artificial joint surfaces and adsorption of bacterium. Fluoroalkylation is one of the surface modification methods, decreasing surface free energy.It has been hypothesized that modification of biomaterial used for total replacement joint surfaces may decrease coefficient of friction (CF) and adsorption of bacterium as a result of decreasing surface free energy. The purpose of this study is to test this hypothesis, assessing the CF of modified Ultra-High Molecular Weight Polyethylene (UHMWPE) and Polycrystal Alumina Ceramic (PCAC).UHMWPE and PCAC were fluoroalkylated using fluoroalkyl end-capped silane coupler. Decreasing surface free energy and fluoroalkylation for biomaterial were confirmed. CF between UHMWPE and PCAC (control or modified) was measured with a mechanical spectrometer using disc on disc geometry with changing of angular velocity. A vertical load was applied on the disc at 250 kPa. CF of modified PCAC against UHMWPE was significantly decreased at all range of angular velocity.Fluoroalkylation is an easy method of surface modification that polymerizes fluoroalkyl group on material surface in very thin layer. There has a possibility of clinical use in fluoroalkylation for biomaterial to resolve complications following total joint arthroplasty.