New DDS for improving joint lubrication and accelerating the restoration of cartilage

新型 DDS 可改善关节润滑并加速软骨修复

• 批准号: 18591672
• 负责人: KITANO Toshio
• 金额: $ 2.28万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591672/
• 关键词: DDS; Articular cartilage; Liposome; Joint lubrication; Intra-artuicular injection; in-vivo; リポソーム化; in-vivo実験; ヒアルロン酸ナトリウム; 変形性関節症; 治療薬; 変性関節軟骨; 軟骨欠損; 関節形成術; 内包率

The purpose of this study is to clarify the effect of new drug delivery system(DDS) in vivo study. This new DDS is liposome build of Lα-dipalmitoylphosphatidylcholine (DPPC) include Hyaluronic acid which would improve the joint lubrication and restore the degenerative or damaged articular cartilage.Using rabbit's knee joint, our new DDS was injected into the knee joint. One, seven and fourteen days after injection, Concentration of the joint effusion was measured and inflammation sign of synovium and cartilage were inspected.Concentration of the joint effusion the new DDS injected was two times as that of control. Inflammation sign of synovium and cartilage were not observed in any specimen.The result of this study is one of the biggest steps to use this for the clinical therapy.

本研究的目的是阐明新的给药系统（DDS）在体内研究中的作用。这种新型DDS是由l - α-二棕榈酰磷脂酰胆碱（DPPC）脂质体构建而成，含有透明质酸，能改善关节润滑，修复退行性或受损的关节软骨。利用兔膝关节，将新型DDS注射到膝关节内。注射后第1、7、14天测定关节积液浓度，观察滑膜和软骨的炎症征象。注射新型DDS后关节积液浓度为对照组的2倍。所有标本均未见滑膜和软骨的炎症征象。这项研究的结果是将其用于临床治疗的最大步骤之一。