New DDS for improving joint lubrication and accelerating the restoration of cartilage

本研究的目的是阐明新的给药系统（DDS）在体内研究中的作用。这种新型DDS是由l - α-二棕榈酰磷脂酰胆碱（DPPC）脂质体构建而成，含有透明质酸，能改善关节润滑，修复退行性或受损的关节软骨。利用兔膝关节，将新型DDS注射到膝关节内。注射后第1、7、14天测定关节积液浓度，观察滑膜和软骨的炎症征象。注射新型DDS后关节积液浓度为对照组的2倍。所有标本均未见滑膜和软骨的炎症征象。这项研究的结果是将其用于临床治疗的最大步骤之一。

The purpose of this study is to clarify the effect of new drug delivery system(DDS) in vivo study. This new DDS is liposome build of Lα-dipalmitoylphosphatidylcholine (DPPC) include Hyaluronic acid which would improve the joint lubrication and restore the degenerative or damaged articular cartilage.Using rabbit's knee joint, our new DDS was injected into the knee joint. One, seven and fourteen days after injection, Concentration of the joint effusion was measured and inflammation sign of synovium and cartilage were inspected.Concentration of the joint effusion the new DDS injected was two times as that of control. Inflammation sign of synovium and cartilage were not observed in any specimen.The result of this study is one of the biggest steps to use this for the clinical therapy.