Investigation on Relationship Between Physical Activity and Human Sleep-Awake Cycle by Temporal Isolation

我们调查了人类体力活动和睡眠-觉醒周期之间的关系。首先，我们开发了一种便携式数据记录器来持续监测心率和身体运动，并开发了一种方法来揭示心率昼夜节律，而不是与体力活动相关的组件。常规恒定实验和时间隔离实验结果均表明，无掩蔽心率昼夜节律与核心体温昼夜节律具有较好的一致性。接下来，在时间隔离期间，研究每日低强度体力活动(3小时)对核心体温和心率昼夜节律的影响。研究发现，白天的体力活动使昼夜节律落后于前几天。最后，我们研究了日常运动对慢性疲劳综合征患者昼夜运动活动的影响。结果表明，运动后患者的昼夜静息-活动时间延长，表明力竭运动干扰了24小时的正常牵引(S)。这种效应可能在一定程度上解释了常见的患者主诉症状在运动后恶化的原因。

We investigated the relationship between physical activity and sleep-awake cycles in humans. First, we developed a portable data logger to continuously monitor heart rate and body movement and a method to unmask the heart rate circadian rhythm free from components related to physical activity. Both the results of constant routine and temporal isolation experiments revealed that the unmasked heart rate circadian rhythm was in good agreement with the core temperature circadian rhythm. Next, the effects of diurnal low intensity physical activity (3 hr) on core temperature and heart rate circadian rhythms were examined during temporal isolation. It was found that the diurnal physical activity shifted the circadian rhythms behind those of previous days. Finally, we investigated the effects of diurnal exercise on the circadian locomotor activity in patients with chronic fatigue syndrome. It was shown that circadian rest-activity periods of the patients were increased following exercise, indicating that exhaustive exercise interferes with normal entrainment to 24 h zeitgeber(s). This effect may explain, in part, the common patient complaint of symptom worsening following exertion.