Development of novel photoreaction-driven percutaneous devices in cardiovascular field

经皮治疗作为心血管领域的一种低侵入性治疗，其设备和技术的发展在心血管领域具有重要意义，尤其是在老年人众多的社会。其中包括：1)可见光诱导组织粘合剂，在几分钟的可见光照射下，将含有樟脑醌的苯乙烯明胶和/或白蛋白水溶液凝胶化；2)用于脑动静脉畸形和局部输送细胞因子的栓塞剂；3)具有微孔和药物输送性能的新型高功能覆膜支架和水凝胶涂层支架，用于预防再狭窄和额外的基因输送装置；4)具有血管扩张、血液循环和局部给药三大功能的高性能球囊导管，所有这些都是由光化学驱动的。此外，我们还致力于基因治疗设备的应用。我们是开发这些技术的先驱，这些技术将成为心血管疾病治疗的核心。

The development of the devices and techniques for percutaneous treatment as a low invasion therapy in cardiovascular field are important especially in societies with many elderly people. Among them we have developed are as follows ; 1) visible light-induced tissue adhesive glue where styrenated gelatin and/or albumin-containing aqueous solutions with camphorquinone were gelated upon a few minutes of visible light irradiation, 2) embolic material for cerebral arteriovenous malformations and for local delivery of cytokines, 3) a novel high functional covered stent with micropore and drug delivery performance and hydrogel-coated stents both for prevention of restenosis and additionally a gene delivery device, and 4) the high performance balloon catheters with three functions of dilation of blood vessels, blood circulation and local delivery of drugs, all of which were driven by photochemistry. In addition, our efforts are also directed to application of gene therapy devices. We are pioneers in the development of these technologies and these techniques that will become the central in treatment of cardiovascular diseases.