Spatio-Temporal Integrated Instrumentation and Evaluation of Biomedical Structures and Functions from Time Varying Images

为了理解生理功能或运动动力学，将几个观测图像数据和数值模型结合起来是非常有用的。然而，用计算机处理这些数据有几个问题，特别是在目标难以描述其结构和/或涉及复杂运动的情况下。为此，我们开发了一种数据采集系统，该系统可以方便地从多摄像机观测中获取3D运动数据，并将3D动态数据的呈现与假设模型相结合。新设计的记录系统展示了对包含多个相关时间序列信号的图像序列的捕获能力，然后使用参考信号进行图像分析。构建了基于彩色标记物的双摄像机系统来获取人体的3D运动，并设计了一种简便的程序，无需精确的摄像机标定即可通过双摄像机系统获得归一化的具有合理图像质量的3D图像序列；通过制作数字人体模型，我们开发了数字运动仿真系统，可以对足球踢球运动进行多项量化评价。针对心脏临床评估的情况，我们开发了一个交互式三维显示系统，将SPECT的功能信息叠加到MRI的三维形态描述上。我们已经成功地展示了荧光X射线CT与透射式或康普顿散射式X射线CT的集成处理效率，通过使用同步辐射X射线来评估特定物质在人体器官中的分布。我们还在光学和超声成像、图像处理程序方面取得了一些进展，建立了我们的项目，包括对这种三维图像数据在计算机网络环境下的使用进行了一些讨论。

For understanding of physiological functions or sports dynamics, it is quite useful to integrate several observed image data and numerical models. However, there are several problems to manipulate such data by computer especially in cases of targets difficult to describe their structure and/or involving complex motion. So we have developing a data capturing system for this purpose, easy procedure to obtain 3D motion data from multi-camera observation, and integrated presentation of 3D dynamic data with assumed model.Newly designed recording system demonstrated capturing ability for image sequence with several related time series signals, then image analysis is performed with reference signals. A two-camera system using color markers isalso constructed to obtain human 3D motion, and designed a convenient procedure to get normalized 3D image sequence with reasonable image quality by two-camera system without exact camera calibration.By preparing digital human model, we have developed numerical sports simulation system and we can get several quantitative evaluations on the kick motion of football. Dynamic analysis of javelin throw has been also started and the fusion of 3D observation and computer simulation is in the next step.For the case of clinical evaluation of heart, we have developed an interactive 3D display system where functional informations from SPECT are superposed on 3D morphological description from MRI. We have succeeded to demonstrate the efficiency of integrated processing of fluorescent X-ray CT with transmission or Compton scattering X-ray CT by using synchrotron radiation X-ray to evaluate distribution of specific materials in human organ.We have also gotten several progresses in optical and ultrasound imaging, image-processing procedures to establish our project including a few discussions on usages of such 3D image data under computer network circumstances.