Comprehensive Study for the Relationship between Stress, Periodontal Disease and Systemic Disease

为了探讨生活事件应激对牙周病发生和发展的影响，从基础和临床两个方面进行了团队研究。横田等人。分析心理问卷测量的压力影响与牙周炎和龋病发生的关系。结果表明，应激程度与牙周炎、龋齿之间不存在简单的线性相关关系，但与吸烟状况呈显著正相关。多因素分析揭示了心理应激、吸烟与牙周炎的关系。Kawanami et.艾尔。调查糖尿病患者的牙周炎和应激情况。对200多名糖尿病患者进行的多因素分析显示，压力和失眠与牙周炎有显著关系。吉那利等人。艾尔。采用实验性牙周炎大鼠模型，观察机械应力对牙周炎进展的影响。机械应激导致大鼠体重下降，血糖升高，血ACTH升高。TatSumi et.艾尔。研究了小鼠骨髓中的破骨细胞。结果表明，地塞米松可促进TRAP阳性多核细胞的形成，并诱导主动骨吸收。Kido et.艾尔。研究了P物质在内毒素存在下对成骨细胞产生炎性细胞因子的影响。结果表明，P物质促进成骨细胞产生细胞因子，抑制成骨细胞分化。

To investigate the influence of stress in life event on the occurrence and progression of periodontal disease, team studies had been performed from basic aspect and clinical aspect. Yokota e. al. analyzed the relationship between the impact of stress measured with psychological inventories and the occurrence of periodontitis and caries. Result showed no simple linear correlation between stress scale and periodontitis or caries, but significant positive correlation between stress and smoking status. Multivariate analysis revealed the possibility of the relationship between psychological stress, smoking and periodontitis. Kawanami et. Al. investigated periodontitis and stress of diabetes patents. Multivariate analysis using more than 200 diabetes patients showed significant relationship stress and sleeplessness on periodontitis. Yoshinari et. Al. used the experimentally-induced periodontitis rat model to investigate the influence of mechanical stress on the progression of periodontitis. Mechanical stress on rat induced low body weight, increased blood glucose and increased blood ACTH. Tatsumi et. Al. studied osteoclast from mouse bone marrow. The result showed dexamethasone promoted the formation of TRAP-positive multinuclear cells and induced active bone resorption. Kido et. Al. investigated the effect of substance P, known as one of the immune mediators related to stress, on the production of inflammatory cytokines from osteoblast cells under the presence of LPS. The result showed that substance P enforced the production of cytokines from osteoblast and inhibit the differentiation of osteoblast.