Preparation of biomedical materials by the optimum hybridization of self-assembling polymeric nanospheres and biopolymers

疏水单体与亲水性大单体在极性溶剂中无乳化剂的自由基分散共聚得到单分散的高分子纳米球，多相聚合物自组装形成纳米球的机理表明亲水性大单体链覆盖在纳米球表面以减少核-电晕聚合物纳米球。采用大单体法，可以制备出多种核-电晕型高分子纳米球，其表面易于用大单体链修饰。在这项研究中，生物聚合物或生物分子，如(1)作为药物的肽，(2)用于识别蛋白质的碳水化合物，(3)提供生物激发聚合物表面的磷脂类似物，以及(4)分别用于捕获HIV-1和HIV-1疫苗的凝集素和HTV-1，被固定在聚合物纳米球的电晕上。研究结果表明，自组装高分子纳米球与生物聚合物的最佳杂交是制备高功能粒子的关键，对生物医用材料的设计具有重要意义。

Free radical dispersion copolymerization of hydrophobic monomers with hydrophilic macromonomers in a polar solvent without any emulsifier gives monodispersed polymeric nanospheres, and the nanosphere formation mechanism based on self-assembling of multiphase polymers suggests that hydrophilic macromonomer chains cover the surface of the nanospheres to reduce core-corona polymeric nanospheres. Using the macromonomer method, a variety of core-corona polymeric nanospheres can be prepared and their surface can be easily modified by macromonomer chains.In this study, biopolymers or biomolecules such as (1) peptides as medicine, (2) carbohydrates for the recognition of proteins, (3) phospholipids analog for giving a bioinspired polymer surface, and (4) lectin and HTV-1 for capturing HIV-1 and HIV-1 vaccine, respectively, were immobilized on the corona of polymeric nanospheres. We concluded that the optimum hybridization of self-assembling polymeric nanospheres and biopolymers is a key of highly functional particle preparation and important for design of biomedical materials.