High-selective HPLC with chiral organogels

最近，有机凝胶系统很有吸引力。这是因为它们可以通过与低分子化合物形成三维纤维网络来生产，而传统的水凝胶主要是通过非晶聚合物的部分交联来生产的。因此，有机凝胶系统往往伴随着超分子功能，如手性增强。然而，与水凝胶系统相比，有一些明显的缺点。最严重的问题是由于有机凝胶在机械上是脆弱的。因此，我们尝试聚合有机凝胶以扩展其可能的应用。在本研究中，我们重点研究了有机凝胶体系在高效液相色谱分离中的应用。为此，我们设计了(1)新的有机凝胶形成的亲脂化合物（脂），并研究了它们的物理化学性质，如手性和有序结构。通过(2)光诱导聚合本研究制备的可聚合脂类和(3)本体溶液与不可聚合脂类的自由基聚合，实现了有机凝胶的稳定。(4)以手性脂质固定化二氧化硅为填料进行了高效液相色谱分离，并以芳烃为样品讨论了分子形状选择性和手性识别能力。

Recently, organogel systems have been attractive. This is due to the facts that they can be produced through three-dimensional fibrous network formation with low-molecular compounds although conventional hydrogels are mostly produced by partial crosslinking of amorphous polymers. Therefore, organogel systems are often accompanied by supramolecualr functions such as enhancement of chirality. However, there are some distinct disadvantages compared with hydrogel systems. The most serious problem is due to the fact that organogels are mechanically fragile. Therefore, we have tried to polymerize organogels to extend their possible applications. In this study, we have focused on application of organogel systems for HPLC separation by stabilization of organogels. For this purpose, we designed (1)novel organogel-forming lipophilic compounds (lipids) and their physicochemical properties such as chirality and ordered structures were investigated. Also stabilization of organogels was carried out by (2)photo-induced polymerization of the polymerizable lipids prepared in this study and (3)radical polymerization ofa bulk solution with the non-polymerizable lipids. Also (4)HPLC separation has carried out with the chiral lipid-immobilized silica as packing materials and molecular-shape selectivity and chiral recognition ability were discussed with aromatic hydrocarbons as samples.