Clinical evaluation and basic research for long term use of a newly developed miniature mixed-flow pump

我们对新开发的微型混合血流泵（MFP）在体外循环（CPB）中的长期应用进行了临床评估和基础研究。在临床评估中，10例患者接受了CPB和MFP。泵流量保持稳定。在启动和断奶状态下，MFP控制非常平稳。血浆游离血红蛋白、乳酸脱氢酶、血小板计数、β-血栓球蛋白和凝血酶-抗凝血酶复合物的变化与对照组无显著差异。我们认为MFP具有良好的可控性，对血液的损害较小。在7只山羊中建立左心室旁路，以评估其耐久性和抗血栓形成性。在2只山羊中，实验于14天后完成。在轴承周围形成血栓。我们相信轴承的一些改进可以长期使用。

We performed a clinical evaluation and a basic research for long term use of a newly developed miniature mixed-flow blood pump (MFP) for cardiopulmonary bypass (CPB). In the clinical evaluation, 10 patients received a CPB with the MFP. The pump flow was maintained steadily. The MFP was controlled very smoothly at starting and weaning state. Changes in plasma free hemoglobin, lactate dehydrogenase, platelet count, β-thromboglobulin and thrombin-antithrombin complex showed no significant differences from those of a control pump. We believe the MFP had good controllability and less damage on the blood. Left ventricular bypasses were established in 7 goats to evaluate durability and antithrombogenesity. In two goats, experiments were finished after 14 days bypass. Thrombus formations were obtained around a bearing. We believe some improvements of bearings for long term use.