Motor learning-induced plasticity of cerebellar Purkinje neuron connectivity (A03)

A03项目解决了浦肯野细胞(PC)突触可塑性在调节小脑皮层连通性变化方面的意义，这些变化是在小鼠模型中的运动学习和协调基础上的。将结合老鼠遗传学、活体成像和创新的追踪方法。这些发现将扩展到患有小脑运动学习障碍或共济失调的小鼠模型，以揭示PC连接的潜在后果。

Project A03 addresses the significance of Purkinje cell (PC) synaptic plasticity in accommodating cerebellar cortex connectivity changes underlying motor learning and coordination in a mouse model. A combination of mouse genetics, live imaging, and innovative tracing approaches will be used. Findings will be extended to mouse models suffering from disrupted cerebellar motor learning or ataxia, to disclose the underlying consequences for PC connectivity.