Targeting the neurovascular niche in COVID-19

严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)导致2019年冠状病毒病(新冠肺炎)，并已演变为全球大流行。SARS-CoV-2主要针对呼吸道，但神经系统特征在新冠肺炎患者中常见。然而，SARS-CoV-2导致神经系统症状的原因尚不清楚。在神经病理学上，新冠肺炎患者在没有明显病毒性脑炎症状的情况下表现出微血管病变。在这里，我们利用现代形态学和转录分析工具对新冠肺炎患者脑内神经免疫介导的机制进行研究，以期更好地了解神经血管生态位在新冠肺炎病理生理中的作用。

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19) which has evolved into a global pandemic. SARS-CoV-2 primarily targets the respiratory tract, yet neurologic features are frequent in COVID-19 patients. However, the reasons why SARS-CoV-2 leads to neurologic symptoms is not well understood. Neuropathologically, COVID-19 patients show microvascular pathology in the absence of overt sings of viral encephalitis. Here we investigate neuroimmune-mediated mechanism in brains of COVID-19 patients using modern tools of morphology and transcriptional analysis with the aim to better understand the role of the neurovascular niche in the pathophysiology of COVID-19.