Application of antisense-peptides associated with immunological rection in organ transplantation

在同种异体移植中，淋巴细胞和抗原呈递细胞之间的相互作用是继各种类型的免疫应答之后的关键事件。来自移植物的抗原呈递细胞在导致移植物的增强的排斥反应的初始反应中也起重要作用。近年来，这种供体移植物衍生的抗原呈递细胞被认为在远离移植部位的宿主中保留相当长的时间，特别是在长期存活者中观察到。这导致了它与微嵌合体关系的重要性的概念。在目前的研究中，我们集中在免疫应答蛋白的肽的作用，特别是那些与供体来源的抗原呈递细胞。本研究的主要目的是：1）阐明同种异体移植免疫耐受诱导的分子生物学机制，2）了解细胞表面蛋白和细胞内物质及其信号转导，3）分析免疫耐受应答的反义肽，4）研究免疫耐受的分子机制。4）诱导耐受性的临床前研究免疫应答蛋白可以含有决定生物活性的肽部分，其通常由有限长度的肽组成，其一个很好的例子是Fas抗原和配体蛋白。本研究的结果表明，通过关注器官移植中免疫应答细胞之间的生物活性蛋白的相互作用，可以实现比常规方法更好的免疫调节，

In allograft transplantation, interaction between lymphocytes and antigen presenting cells is a key event followed by various types of immunological response. The antigen presenting cell from the graft also plays an important role in the initial response leading to an augmented rejection response of the graft. In recent years, such donor graft-derived antigen presenting cells are considered to remain for a considerable length of time in the host remote from the graft site that is observed particularly in the long-term survivors. This has led to the concept of its significance in relation to a microchimerism. In the present research, we have focused on the role of peptides of the immunologically responsive proteins, particularly those associated with donor-derived antigen presenting cells. The following are the main aims of the present study in the investigation for : 1) clarification of molecular-biological mechanism in the induction of immunological tolerance in the allograft transplantation ; 2) insights for cell surface proteins and intra-cellular substances and their signal transduction ; 3) analysis of antisense peptides responsive for immunological tolerance ; 4) preclinical study for induction of tolerance.Immunologically responsive proteins can contain portions of peptides which determine the bioactivity that are usually consisted of a limited length of peptides, a good example of which is a Fas antigen and ligand protein. The results of the present study indicate that a better immunological regulation than a conventional method can be achieved by focusing on the interaction of the bioactive proteins between the immunologically responsive cells in the organ transplantation,