Practical Synthetic Reactions for Tine Chemical Using a Divalent Titanium Reagent

由Ti (O-I-Pr)_4和两种等价物I-PrMgCl制备的二价钛试剂无毒、廉价，具有多种反应活性。因此，该试剂已被许多合成化学家广泛使用。利用该试剂对反应的进一步研究开辟了以下提到的新的高效合成方法。1)制备1α， 25-二羟基维生素D_3的实用合成方法，该试剂介导双不饱和化合物的环化是关键反应。2)由旋光性烯丙基和丙炔基化合物分别合成手性烯丙基和烯丙基钛试剂的方法及其合成利用。3)开发了内端乙炔的金属化Reppe反应及其试剂，使苯和吡啶衍生物易于获得。4) 1,4-二碘-1,3-烷二烯的实用制备方法及其在多取代共轭达因和π共轭线性低聚物中的应用。

A divalent titanium reagent developed by us which can be prepared from Ti (O-I-Pr)_4 and two equivalents of I-PrMgCl is non-toxic and inexpensive, and has versatile reactivity. The reagent therefore, has become widely used by many synthetic chemists.Further study of the reactions using the reagent opens up new efficient synthetic methods mentioned below.1) Practical synthetic method for preparing 1α, 25-dihydoxy-vitamin D_3 in which cyclization of bis-unsaturated compounds mediated by the reagent is a key reaction.2) Synthetic method of chiral allyl and alleyl titanium reagent from optically active allyl and propargyl compounds, respectively, and their synthetic utilization.3) Development of metalative Reppe reaction from internal and terminal acetylene and the reagent, which allows easy access to benzene and pyridine derivatives.4) Practical method to prepare 1,4-diiodo-1,3-alkadienes and their utilization for synthesizing polysubstituted conjugated dynes and π-conjugated linear oligomers.