An Integrated Approach to Diversity-Oriented Synthesis
面向多样性的综合综合方法
基本信息
- 批准号:7285266
- 负责人:
- 金额:$ 183.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-09-30 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcetyleneAdoptedAlkaloidsAreaAzidesBiologicalBiologyBromineChemicalsChemistryCollaborationsCollectionConditionCouplingCyclizationDescriptorDevelopmentEnsureLactamsLeadLibrariesLinkMediatingMedicineMolecularNumbersPathway interactionsPhasePlacementProcessQuality ControlRangeRateReactionReagentResearchResearch PersonnelRobotRoboticsScreening procedureSiliconSkeletal systemSkeletonSolidSolutionsStandards of Weights and MeasuresTechnologyTransition ElementsVariantWorkalkyl groupappendagecatalystcheminformaticsconceptcycloadditionfundamental researchnovelprogramssizesmall moleculestereochemistrytoolvirtual
项目摘要
DESCRIPTION (provided by applicant): Diversity-oriented synthesis (DOS) has the potential to empower academic chemists and biologists to explore the relationship between chemistry space and biological activity, leading to major advances in biology and medicine. The Center will perform fundamental research to advance the technology and pathways available for DOS, to help realize its full potential. We will develop a new platform (megabeads) that is optimized for screening by biologists; we will use DOS to discover new catalysts, increasing the range of DOS pathways available; and we will develop several new strategies for library synthesis that explore areas of chemical space that are currently sparsely populated. Two Cores will support the Projects. The Library Synthesis, Formatting and Curation Core will work to automate reaction development, currently the rate-limiting step in DOS, and will make the crucial link to biological screening by providing our libraries to the existing ICCB screening facility in a common format. The Cheminformatics Core will compute molecular descriptors for planned libraries, compare them to a reference set of known molecules, and advise Project researchers on ways to maximize the contribution of a given library to the exploration of chemical space.
描述(由申请人提供):多样性导向合成(DOS)有潜力使学术化学家和生物学家探索化学空间与生物活性之间的关系,从而导致生物学和医学的重大进步。该中心将进行基础研究,以推进DOS可用的技术和途径,帮助实现其全部潜力。我们将开发一个新的平台(megabead),优化生物学家的筛选;我们将利用DOS发现新的催化剂,增加DOS途径的可用范围;我们将开发几种新的图书馆合成策略,探索目前很少有人涉足的化学空间领域。两个核心将支持这些项目。库合成、格式和管理核心将致力于自动化反应开发,目前是DOS中的限速步骤,并将通过将我们的库以通用格式提供给现有的ICCB筛选设施,从而与生物筛选建立关键联系。化学信息学核心将计算计划文库的分子描述符,将它们与已知分子的参考集进行比较,并就如何最大化给定文库对化学空间探索的贡献向项目研究人员提供建议。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
STUART L SCHREIBER其他文献
STUART L SCHREIBER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('STUART L SCHREIBER', 18)}}的其他基金
Studies of Materials with Physiological Properties
具有生理特性的材料的研究
- 批准号:
10187586 - 财政年份:2018
- 资助金额:
$ 183.95万 - 项目类别:
Studies of Materials with Physiological Properties
具有生理特性的材料的研究
- 批准号:
10424480 - 财政年份:2018
- 资助金额:
$ 183.95万 - 项目类别:
Targeting vulnerabilities of therapy-resistant cancer cell states with small molecules
用小分子靶向治疗耐药的癌细胞状态的脆弱性
- 批准号:
10227768 - 财政年份:2017
- 资助金额:
$ 183.95万 - 项目类别:
Targeting vulnerabilities of therapy-resistant cancer cell states with small molecules
用小分子靶向治疗耐药的癌细胞状态的脆弱性
- 批准号:
9362107 - 财政年份:2017
- 资助金额:
$ 183.95万 - 项目类别:
Cancer dependencies associated with genomic alterations and targeted by small mol
癌症依赖性与基因组改变相关并通过小分子靶向
- 批准号:
8657018 - 财政年份:2013
- 资助金额:
$ 183.95万 - 项目类别:
Cancer dependencies associated with genomic alterations and targeted by small mol
癌症依赖性与基因组改变相关并通过小分子靶向
- 批准号:
8494988 - 财政年份:2013
- 资助金额:
$ 183.95万 - 项目类别:
Targeting Causal Cancer Genes with Small Molecules
用小分子靶向致癌基因
- 批准号:
8464829 - 财政年份:2009
- 资助金额:
$ 183.95万 - 项目类别:
Targeting Causal Cancer Genes with Small Molecules
用小分子靶向致癌基因
- 批准号:
7944135 - 财政年份:2009
- 资助金额:
$ 183.95万 - 项目类别:
Targeting Causal Cancer Genes with Small Molecules
用小分子靶向致癌基因
- 批准号:
7852284 - 财政年份:2009
- 资助金额:
$ 183.95万 - 项目类别:
相似海外基金
How novices write code: discovering best practices and how they can be adopted
新手如何编写代码:发现最佳实践以及如何采用它们
- 批准号:
2315783 - 财政年份:2023
- 资助金额:
$ 183.95万 - 项目类别:
Standard Grant
One or Several Mothers: The Adopted Child as Critical and Clinical Subject
一位或多位母亲:收养的孩子作为关键和临床对象
- 批准号:
2719534 - 财政年份:2022
- 资助金额:
$ 183.95万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633211 - 财政年份:2020
- 资助金额:
$ 183.95万 - 项目类别:
Studentship
A material investigation of the ceramic shards excavated from the Omuro Ninsei kiln site: Production techniques adopted by Nonomura Ninsei.
对大室仁清窑遗址出土的陶瓷碎片进行材质调查:野野村仁清采用的生产技术。
- 批准号:
20K01113 - 财政年份:2020
- 资助金额:
$ 183.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2436895 - 财政年份:2020
- 资助金额:
$ 183.95万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633207 - 财政年份:2020
- 资助金额:
$ 183.95万 - 项目类别:
Studentship
The limits of development: State structural policy, comparing systems adopted in two European mountain regions (1945-1989)
发展的限制:国家结构政策,比较欧洲两个山区采用的制度(1945-1989)
- 批准号:
426559561 - 财政年份:2019
- 资助金额:
$ 183.95万 - 项目类别:
Research Grants
Securing a Sense of Safety for Adopted Children in Middle Childhood
确保被收养儿童的中期安全感
- 批准号:
2236701 - 财政年份:2019
- 资助金额:
$ 183.95万 - 项目类别:
Studentship
A Study on Mutual Funds Adopted for Individual Defined Contribution Pension Plans
个人设定缴存养老金计划采用共同基金的研究
- 批准号:
19K01745 - 财政年份:2019
- 资助金额:
$ 183.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Structural and functional analyses of a bacterial protein translocation domain that has adopted diverse pathogenic effector functions within host cells
对宿主细胞内采用多种致病效应功能的细菌蛋白易位结构域进行结构和功能分析
- 批准号:
415543446 - 财政年份:2019
- 资助金额:
$ 183.95万 - 项目类别:
Research Fellowships