Role of vertical transmission of HTLV-I on the risk for T cell malignancy

宿主对HTLV-I的免疫反应水平在HTLV-I感染个体中有所不同。在本研究中，我们检测了htlv - i传播途径对宿主抗htlv - i免疫反应的影响。将htlv - 1感染的细胞接种具有免疫能力的成年大鼠后，经口腔感染的大鼠持续感染htlv - 1，无针对htlv - 1的体液和细胞免疫应答，而经静脉或腹腔接种的大鼠均表现出显著的免疫应答。在HTLV-I感染大鼠的后代中也观察到类似的针对HTLV-I的体液和细胞免疫缺陷。这些观察结果表明，宿主抗htlv - i免疫可能受到原发感染条件的影响，特别是在。本研究提供了一个实验证据，垂直传播可能是HTLV-I细胞介导免疫低下的原因，这被认为是成人T细胞白血病的危险因素之一。

The level of host immune responses against HTLV-I varies among HTLV-I-infected individuals. In the present study, we examined the effect of the routes of HTLV-I-transmission on the host anti-HTLV-I immune responses. When immune competent adult rats were inoculated with HTLV-I-infected cells, the orally infected rats were persistently infected with HTLV-I without humoral and cellular immune responses against HTLV-I, whereas all intravenously or intraperitoneally inoculated rats showed significant levels of immune responses. Similar defects of humoral and cellular immunity specific for HTLV-I were observed in offsprings from HTLV-I infected rats. These observations indicated that host anti-HTLV-I immunity can be affected by the conditions of the primary infection, especially in. This study provides an experimental evidence that vertical transmission can be a reason for low cell-mediated immunity against HTLV-I, which is considered to be one of the risk factors for adult T cell leukemia.