Study to prepare safe educational bacterial strains for medical education

通过本研究，我们构建了安全的细菌菌株，用于教育目的。因为3级和2级强毒细菌病原体被要求用于医学教育。然而，大多数大学都没有相应的教育设施。大多数医学院校没有为学生的教学房间准备3类设施。我们收集了降低3级病原菌致病水平的信息，并选择了候选菌株作为教育目的。大多数候选菌株都被剔除了致病因素。我们建议降低这些被剔除的致病因子菌株的生物安全水平。这些毒株应该在研究人员中广泛分布，以评估其未来的安全水平。

Through this study, we constructed safe bacterial strains for educational purpose. Because level 3 and potent toxigenic level 2 bacterial pathogens are requested to use for medical education. However, most of university does not have appropriate facility for education. Class 3 facility is not prepared for student teaching room at most of medical universities. We collected information to decrease the level of pathogenicity for level 3 pathogens and selected candidate strains for educational purpose.Most candidate strains are knocked out their pathogenic factors. We propose to decrease biosafty level of these knocked out strains ofpathogenic factors. These strains should be widely distributed among researchers to evaluate their safety level in future