The long term health effects of the exposure to sarin and by-products

暴露于沙林和副产品的长期健康影响。生物监测：我们对接触物质的代谢物进行了分析，结果表明，患者不仅接触到沙林，还接触到了氟化物和含有沙林合成副产物的异丙醇。其中一种代谢物，甲孕酮的排泄量远远超过了人体致死剂量的沙林，每人排泄量与症状的严重程度呈负相关。虽然甲孕酮排泄量高，但病死率很低，每4人中就有1人死于我科重症监护室(回族、南美、临床区)。詹姆。学报2000；302：171-188)2.对中枢和自主神经系统的影响；在灾难发生3年后进行了横断面流行病学研究。对56名男性接触者和52名年龄和职业相匹配的参照者进行了中枢神经和自主神经功能的测试。暴露组在记忆功能的反向数字广度测试和本顿视觉保持测试中表现较差。测试结果与创伤后应激障碍症状无关。这些结果提示记忆功能的慢性下降(环境，Hlth Perspect。2001年；1169-1173)。其他研究正在进行中；i)作为脱氧核糖核酸功能标志物之一的S，患者尿中8-羟基脱氧鸟苷的排泄目前正在研究中。Ii)我们发现了一种代谢有机磷的同工酶，对氧磷酶。我们发现该酶的最适pH为6.5。

The long term health effects of the exposure to sarin and by-products.1. Biological monitoring ; We assayesd the metabolites of exposed substances and the results suggested that the patients were exposed to not only sarin but also fluoride and isopropanol containing by-products daring sarin synthesis. One of the metabolites, MPA excreted was far exceeding the human lethal dose of sarin and the amount of MPA excretion per person was inversely correlated with the garvity of the symptom. Even though the high level of MPA excretion, the lethality was low 1 death / 4 person received medical treatment in our ICU (Hui and Minami, Clin. Chim. Acta 2000 ; 302 : 171 - 188).2. The effects on central and autonomic nervous systems ; A cross-sectional epidemiological study was conducted 3 years after the disaster. 56 male exposed and 52 referent spersons matched for age and occupation were tested concerning various kinds of central and autonomic nervous functions. The exposed group performed less well in backward digit span tests of memory function and Benton visual retention test. The test results has no relationship with PTSD symptoms. These results suggested the chronic decline in memory function (Environ, Hlth Perspect. 2001 ; 1169 - 1173).3. Other studies now in progress ; i) One of the marker s of abberated DNA function, 8-hydroxy deoxiguanosine excretion in the urine of patients is now under study. ii) We find an isozyme which metabolise organic phosphate, paraoxonase. The enzyme which we found has optimal pH 6.5.