Generic and Disease-Specific Mechanisms of Somatic Symptom Persistence Across Diseases (RU SOMACROSS)

持续性躯体症状（PSS）的发病机制被认为是多因素的，涉及生物、心理和社会因素。虽然已经确定了躯体形式障碍和功能综合征患者中PSS的一些危险因素和假定机制，但在躯体疾病背景下对PSS的相应科学研究几乎完全缺乏。各种研究调查了个别问题，例如存在哪些心理社会风险因素以及期望发挥什么作用。然而，以往研究数据的异质性使得很难产生关于跨疾病和综合征的一般风险因素和机制的一致假设。因此，需要对不同疾病和综合征进行可比较的、标准化的高质量数据和分析，以一致地评估哪些因素是通用的，哪些因素是特定条件的。Z项目的总体目标是实现高质量分析、数据汇集、通过创建一个更高层次的结构，考虑到研究单位（RU）SOMACROSS所有项目的内容和设计，对项目进行比较。该项目将允许建立一个全面的结构方程模型（SEM）的基础上的工作模型的RU的PSS。该模型将描述疾病特异性以及联合风险因素及其相互作用，并允许开发预测模型和相关风险评分。该项目将汇集来自各个项目的核心数据集的前瞻性数据，包括10种不同的医疗条件（总N=1392），并使用在三个相同时间点（基线、6个月和12个月随访）评估的核心工具。数据库将由Z项目创建、管理和维护。数据收集过程将由项目管理和监督。大量的变量被认为是相关的PSS和他们的相互作用被认为是复杂的。因此，将生成跨疾病和综合征的躯体症状持续性的纵向SEM。此外，Z项目还为所有项目提供方法支持和跨学科工具箱，涉及方法、测量点、核心工具和成果测量，为促进跨学科研究提供基础设施，并确保所有项目的高标准方法和可比性。该项目的预期结果包括各种疾病和综合征的躯体症状持续性的纵向SEM以及用于早期识别的风险评分。在第二个供资阶段，将验证和校准最后的SEM和由此产生的风险评分。

The etiological mechanism of persistent somatic symptoms (PSS) is considered multifactorial, with biological, psychological and social factors involved. While some risk factors and putative mechanisms for PSS in patients with somatoform disorders and functional syndromes have been identified, corresponding scientific studies for PSS in the context of somatic diseases are almost completely lacking. Various studies have investigated individual issues, for example which psychosocial risk factors exist and what role expectations play. However, heterogeneity of the data of previous studies makes it difficult to generate consistent hypotheses with regard to generic risk factors and mechanisms across diseases and syndromes. Therefore, there is a need for comparable, standardized high-quality data and analyses across different diseases and syndromes to consistently assess which factors are generic and which ones are specific for a given condition.The overall aim of the Z-Project is to enable high quality analyses, data pooling, and comparisons across projects by creating a higher-level structure considering content and design across all projects of Research Unit (RU) SOMACROSS. The Project will allow to build a comprehensive structural equation model (SEM) for PSS based on the working model of the RU. This model will describe disease specific as well as joint risk factors and their interplay and allows the development of a prediction model and of a associated risk score.The Project will pool prospective data from the core dataset from the individual projects including ten different medical conditions (total N=1392) and utilizing the core instruments assessed at three identical points in time (baseline, 6- and 12-months follow-up). The database will be created, managed and maintained by the Z-Project. The data collection processes will be managed and supervised by the project. A large number of variables is considered to be relevant to PSS and their interactions are presumed to be complex. Therefore, a longitudinal SEM of somatic symptom persistence across diseases and syndromes will be generated. Furthermore, the Z-Project provides methodological support and interdisciplinary toolboxes regarding methodology, measurement points, core instruments, and outcome measures across all projects.The project will provide an infrastructure to foster interdisciplinary research and will ensure high standards of methodology and comparability for all projects. The expected results of the project include a longitudinal SEM of somatic symptom persistence across diseases and syndromes and a risk score for early identification. In the second funding phase, the final SEM and the resulting risk scores will be validated and calibrated.