Development of High Performance Blood Purification System using Novel Aromatic Polyimide Hollow Fiber

本文报道了芳香族含氟聚酰亚胺（6 FDA-6 FAP）在急性肾功能衰竭高性能连续性血液净化系统中的应用。为此，通过不同的条件制备了一系列聚酰亚胺多孔膜，并获得了微纳滤膜。我们专注于湿相转化过程作为制备新型多孔膜的方法，因为具有由纳米级结节或孔径设计的纳米级精细结构的膜在临床使用的医疗器械等领域具有极大的兴趣。所得膜具有良好的超滤速率和抗污染性能。确定了制备非对称多孔中空纤维的各种条件。此外，我们发现，多孔膜显示出良好的血液和免疫相容性，在体内和体外的选择性和定向吸附的IgG在表面上。我们已经制造了用于临床使用的切向模块进行试验。

We report the application of aromatic fluorinated polyimide (6FDA-6FAP) to high performance continuous blood purification system for acute renal failure. For this purpose, a series of porous polyimide membranes were fabricated by different conditions, and micro to nanofiltration membranes was obtained. We focused on a wet phase inversion process as method for preparing a novel porous membrane, since the membrane with nano-order-scale fine structure designed from nanoscale nodule or pore sizes is of great interest in areas such as medical device for clinical use. The obtained membrane showed good ultra filtration rate and anti-fouling property. The various conditions to fabricate asymmetric porous hollow fiber were determined. Also, we found that the porous membrane showed excellent blood and immune compatibility both in vivo and in vitro by the selective and oriented adsorption of IgG on the surface. We have manufactured for trial the tangential module for clinical use.