Development to Intravascular Oxygenator Designed by a Novel Gas Permeantion Ultrathin Membrane with Blood Compatibility

具有血液相容性的新型气体渗透超薄膜设计的血管内氧合器的开发

• 批准号: 08558099
• 负责人: NAGAOKA Shoji
• 金额: $ 4.8万
• 依托单位: TOKYO METROPOLITAN UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08558099/
• 关键词: Artificial Organ; Artificial Lung; Fluorinated Polymide; Hollow Fiber; Phase Inversion; Gas Transfer; Biocompatibility; 埋込み人工肺; 含フッ素芳香族ポリイミド; 血液適合性; ECMD

A novel asymmetric hollow fiber of fluorinated polyimide has been fabricated for intravascular oxygenator (IVOX) device. A dry /wet phase in-version process has been aplied to a spinning process to prepare an asymmetric polyimide hollow fiber. The outer surface of the hollow fiber consisted of an ultrathin skin layr. O2 and CO2 transfer rates of the polyimide hollow fiber were much larger than those determined in presently avalable polydimethylsiloxane (PDMS) hollow fiber and the transfer rates were similar to those measured in silicone-layr-coated polypropylene were similar to those measured in silicone-layr-coated polypropylene (Si-PP) hollow fiber.The hemocompatibility of the polyimide hollow fiber without heparinization has been evaluated in vitro and in vivo. The amount of platelets on the polyimide hollow-fiber surface measured in vitro was less than that on PDMS hollow fiber and Si-PP hollow fiber. The formation of thrombus estimated in vivo was not found. This means that the asymmetric polyimide hollow fiber shows excellent biocompatibility.

制备了一种用于血管内氧合器(IVOX)装置的新型不对称氟化聚酰亚胺中空纤维。将干/湿相反相法应用于纺丝工艺，制备了不对称聚酰亚胺中空纤维。中空纤维的外表面由一层超薄的皮肤组成。聚酰亚胺中空纤维的O2和CO2转移率远大于目前可获得的聚二甲基硅氧烷(PDMS)中空纤维的转移率，与有机硅涂层聚丙烯(Si-PP)中空纤维的转移率相近。体外测得的聚酰亚胺中空纤维表面的血小板数量少于PDMS中空纤维和Si-PP中空纤维。没有发现体内估计的血栓形成。这意味着不对称聚酰亚胺中空纤维表现出良好的生物相容性。

项目成果

H.Kawakami, S.Nagaoka: "Development of a Novel Polyimide Hollow Fiber for an Intravascular Oxygenator" ASAIO J.43. 490-494 (1997)

H.Kawakami、S.Nagaoka：“用于血管内氧合器的新型聚酰亚胺中空纤维的开发”ASAIO J.43。

Mitsuyasu Kawano, Hiroyoshi Kawakami, Toshiyuki Ohse, and Shoji Nagaoka: "Syntheses of Polymeric Manganese Porphyrins and Their Evaluation of Targeting Ability to O2" Porphyrin. Vol.5(3). 243-249 (1996)

Mitsuyasu Kawano、Hiroyoshi Kawakami、Toshiyuki Ohse 和 Shoji Nagaoka：“聚合锰卟啉的合成及其对 O2 靶向能力的评估”卟啉。

Hiroyoshi Kawakami, Masato Mikawa, and Shoji Nagaoka: "Gas Permeabiliry and Selectivity Through Asymmetric Polyimide Membranes" J.Appl.Polym.Sci.,. Vol.62(7). 965-971 (1996)

Hiroyoshi Kawakami、Masato Mikawa 和 Shoji Nagaoka：“非对称聚酰亚胺膜的气体渗透性和选择性”J.Appl.Polym.Sci.,。

H.Kawakami: "Gas Transfer and In Vitro and In Vivo Blood Compatibility of Fluorinated Polyimide Membranes with Ultrathin Skin Layer" ASAID Journal. 42・5. M871-M876 (1996)

H. Kawakami：“具有超薄皮肤层的氟化聚酰亚胺膜的气体转移和体外和体内血液相容性”ASAID 杂志 42・5（1996 年）。

Hiroyoshi Kawakami, Masato Mikawa, Jun Takagi, and Shoji Nagaoka: "Gas Transfer and Blood Comatibility of Fluorinated Polyimide Membranes" J.Biomater.Sci., Polym.Ed.Vol.7(12). 1029-1038 (1996)

Hiroyoshi Kawakami、Masato Mikawa、Jun Takagi 和 Shoji Nagaoka：“氟化聚酰亚胺膜的气体传输和血液相容性”J.Biomater.Sci.，Polym.Ed.Vol.7(12)。