Development to Intravascular Oxygenator Designed by a Novel Gas Permeantion Ultrathin Membrane with Blood Compatibility

制备了一种用于血管内氧合器（IVOX）的新型氟化聚酰亚胺不对称中空纤维。采用干湿相法制备了不对称聚酰亚胺中空纤维。中空纤维的外表面由超薄的表皮层组成。聚酰亚胺中空纤维的O2和CO2转移速率远大于现有的聚二甲基硅氧烷（PDMS）中空纤维，与硅包覆聚丙烯中空纤维的O2和CO2转移速率相近，与硅包覆聚丙烯中空纤维的O2和CO2转移速率相近。在体外和体内评价了未经肝素化处理的聚酰亚胺中空纤维的血液相容性。体外测定聚酰亚胺中空纤维表面血小板数量少于PDMS中空纤维和Si-PP中空纤维表面血小板数量。体内未发现血栓形成。这意味着不对称聚酰亚胺中空纤维具有良好的生物相容性。

A novel asymmetric hollow fiber of fluorinated polyimide has been fabricated for intravascular oxygenator (IVOX) device. A dry /wet phase in-version process has been aplied to a spinning process to prepare an asymmetric polyimide hollow fiber. The outer surface of the hollow fiber consisted of an ultrathin skin layr. O2 and CO2 transfer rates of the polyimide hollow fiber were much larger than those determined in presently avalable polydimethylsiloxane (PDMS) hollow fiber and the transfer rates were similar to those measured in silicone-layr-coated polypropylene were similar to those measured in silicone-layr-coated polypropylene (Si-PP) hollow fiber.The hemocompatibility of the polyimide hollow fiber without heparinization has been evaluated in vitro and in vivo. The amount of platelets on the polyimide hollow-fiber surface measured in vitro was less than that on PDMS hollow fiber and Si-PP hollow fiber. The formation of thrombus estimated in vivo was not found. This means that the asymmetric polyimide hollow fiber shows excellent biocompatibility.