Research on functional substances from mushrooms showing preventing or curing effects on some diseases

这个项目是在以下科目下完成的。1)抑制淀粉样蛋白-β细胞毒性物质鉴于蘑菇Hericium erinaceum具有抑制淀粉样蛋白-β细胞毒性的活性，我们试图从蘑菇中分离出抑制淀粉样蛋白-β细胞毒性的活性物质。结果得到了一种磷脂酰乙醇胺。采用核磁共振、质谱、红外等光谱分析方法对其结构进行了表征。2)肝损伤预防物质：通过对香菇、金针菇和灰树花的肝损伤预防活性筛选，发现香菇、金针菇和灰树花具有较强的肝损伤预防活性。从蘑菇中分离活性成分的工作正在进行中。3)抗氧化、抗过敏、抗肿瘤物质培养的林菇菌丝具有抗氧化、抗过敏、抗肿瘤活性。从蘑菇中分离活性成分的工作正在进行中。4)基质金属蛋白酶抑制剂基质金属蛋白酶抑制剂从白桦树Piputoporus betulinus5)神经生长因子诱导剂从猴头菌（Hericium erinaceum）菌丝体中获得神经生长因子诱导剂。这些化合物分别被命名为狐碱H和狐碱I。

This project was done under the following subjects.1) Suppressing substances against amyloid-β cytotoxicitySince the mushroom Hericium erinaceum exhibited suppressing activity against Amyloid-β cytotoxicity, we tried to isolate the active principles from the mushroom. As a result, a kind of phosphatidyl ethanolamine was obtained. The structure was determined by spectroscopic methods such as NMR, MS, IR and so on.2) Liver injury preventing substanceBy the screening for liver injury preventing activity of mushrooms, we found that Lentinus edodes, Flammulina velutipes, and Grifola frondosa had potent activities. The isolation of active principles from the mushrooms are now in progress.3) Anti-oxidant, anti-allergy, anti-tumor substancesThe cultured mycelia of Phellinus linteus showed anti-oxidant, anti-allergy, and anti-tumor activities. Isolation of the active principles from the mushrooms are now in progress.4) Matrix metallo-proteinase inhibitorA matrix metallo-proteinase inhibitor was purified from the mushroom Piputoporus betulinus5) Nerve growth factor inducerNerve growth factor inducers were obtained from the mycelia of Hericium erinaceum. The compounds were named as erinacines H and I.