Presurgical evaluation of epileptic focus with MRI and magnetoencephalography (MEG) for extra-temporal lobe epilepsy surgery.

(1)难治性癫痫患者脑磁图分析的进展分析发作间期棘波放电从早期斜坡到棘波峰值的过程。对发作间期脑磁图棘波的分析使我们能够估计癫痫灶，并预测颞叶外癫痫患者手术后的癫痫发作结局。(2)脑功能磁共振成像（FMRI）脑功能标测在癫痫手术前的应用随着视觉图像处理系统和新软件的出现，对语言、视知觉等脑功能进行精确的脑功能标测成为可能。(3)证实MRI和MEG对癫痫患者术前评估的准确性。数字化EEG工作站的引入使我们能够检查皮层电图，并进行慢性硬膜下网格的直接皮层刺激。术前评估和网格检查之间的比较证实了MEG和MRI在癫痫手术中的有用性。（4）脑磁图和磁共振成像的临床应用：本研究将脑磁图和磁共振成像数据输入系统工作站，并转换成三维重建图像，用于术中神经导航。

(1) The development of MEG analysis for intractable epilepsy patientsInterictal spike discharge was analyzed during the period from the early slope to the spike peak. The present analysis of the interictal MEG spikes enabled us to estimate epileptic focus, and predicted post-surgical seizure outcomes for extra-temporal lobe epilepsy patient.(2) Cortical mapping with functional MRI, as presurgical evaluation for epilepsy surgeryThe introduction of visual image processing system and new software made it possible to perform the accurate functional brain mapping, such as language, and visual perception.(3) Confirmation of the accuracy of presurgical evaluation with MRI and MEG for epilepsy patients.The introductions of digital EEG workstation enabled us to exam electro-corticograms, and perform the direct cortical stimulation with chronic subdural grids. The comparison between presurgical evaluations and grids examinations confirmed the usefulness of MEG and MRI for epilepsy surgery.(4)Clinical applications of both MEG and MRI results.In the present study, both MEG and MRI data were put into the system workstation, and convert to the 3D reconstruction images for intra-operative neuronavigation.