Comparative epidemiogeographic pathlogical study of etiology of oral cancer between Japan and Russia, especially Siberian area

不同国家间的临床病理特征存在一定差异。因此，口腔癌的流行病学研究对于了解该病的确切行为和发病机制具有重要意义。本研究分析了日本、俄罗斯和中国口腔癌的人乳头瘤病毒（HPV）和杂合性缺失（洛）。在日本，我们比较了东京和冲绳的数据，那里的气候是亚热带。我们还分析了冲绳县宫古岛正常居民中HPV的流行情况，以研究HPV的自然史。口腔癌的发病特点之一是多发病，这一现象可以用现场癌变来解释。我们研究了口腔多发性癌的克隆性，即多个癌灶是单克隆还是多克隆起源。本研究表明，多克隆起源的可能性。

There are seen some differences in the clinicopathologic features among the different countries. And so epidemiogeographical Study of the oral cancer is important for understanding the exact behaviors and pathogenesis of this disease. In the present study we analyzed the human papillomavirus (HPV) and loss of heterozygosity (LOH) of the oral cancer from Japan, Russia and China. Among Japanese we compared the data between Tokyo and Okinawa where the climate is semitropical. We also analyzed the prevalence of HPV in the normal inhabitants of Miyako Island of the Okinawa Prefecture, in order to study of natural history of HPV. One of the characteristics in the pathogenesis of oral cancer is multiple occurrences, and this phenomenon might be explained by field cancerization. We studied the clonality of the oral multiple cancers, that is, whether multiple foci of the cancer are of monoclonal or polyclonal origin. The present study suggested the possibility of polyclonal origin.