Study on the self-setting cell regulation membrane aimed for the tissue regeneration

本研究的目的是探讨利用自体屏障膜修复骨缺损的方法。本年度评估了在较大的骨缺损区域使用磷灰石骨水泥或磷灰石形态来保持自凝屏障膜形态。我们发现使用磷灰石水泥或磷灰石形式是非常有效的调节再生骨的形式。尽管我们在磷灰石水泥表面发现了骨导电性，但再生骨的数量有限。另一方面，当我们使用磷灰石形态来保持自凝屏障膜的形状时，我们发现有足够的新骨形成。然而，我们有时发现磷灰石形式破坏了自凝屏障膜。因此，我们认为一些具有高孔隙率的基质有助于保持自定屏障膜的形状并产生再生骨。我们必须选择操作程序，以使支撑基板不会破坏自凝屏障膜。我们还需要研究如何制造具有更高机械强度的自凝屏障膜。

Objective of this investigation was to study method regarding to the regeneration of bone defect using self-setting barrier membrane. In this year, use of apatite cement or apatite form was evaluated to keep the form of self-setting barrier membrane in relatively larger bone defect area. We found that use of apatite cement or apatite form was very effective to regulate the form of regenerative bone. Although we found osteoconductivity on the surface of apatite cement, the amount of regenerated bone was limited.. On the other hand, we found enough new bone formation when we used apatite form to keep the shape of self-setting barrier membrane. However, we sometimes found that apatite form break the self-setting barrier membrane. We concluded therefore that some substrate with high porosity is useful to keep the shape of self-setting barrier membrane arid resulting regenerated bone. We have to select operation procedure so that the supporting substrate would not break the self-setting barrier membrane. We also have to investigate so that self-setting barrier membrane with higher mechanical strength can be fabricated.