The monoaminergic modulation of spinal motor function and the alteration in the motor disease

下降的去甲肾上腺素能和血清素能系统调节控制身体和四肢运动的脊髓α-运动神经元的功能。然而，神经元疾病的功能和变化尚不清楚。在本研究中，获得了以下结果：1。5 -羟色胺能激动剂已显示增加和减少脊髓运动传递。运动神经元具有躯体树突5-羟色胺（5-HT）_2受体，这是兴奋性增加的原因。然而，目前尚不清楚是哪种受体亚型介导了脊髓反射的抑制作用。我们发现位于脊髓中的5-HT_<1B>和5-HT_<1D>受体介导5- ht诱导的脊髓反射抑制。观察链脲佐菌素（STZ）诱导的糖尿病大鼠的脊髓反射、复发性和突触前抑制。甘氨酸介导的糖尿病大鼠的复发性抑制被抑制。5-HT的抑制作用明显减弱。更多的结果表明，糖尿病变性不仅发生在感觉系统，也发生在运动系统。研究了脊髓小脑萎缩（SCD）模型小鼠共济失调与中枢神经系统单胺浓度的关系。以出生后2、3、4 d给予阿拉伯糖胞苷制备的SCD模型小鼠名古屋滚动小鼠（RMN）和阿拉- c小鼠为研究对象。SCD模型小鼠中枢神经系统单胺浓度升高。临床上用于SCD治疗的水合他替雷林可改善共济失调，但不影响RMN和Ara-C小鼠中枢神经系统单胺浓度。结果表明，小鼠的有害刺激诱发屈肌反射由a - δ纤维介导的短潜伏期和c -纤维介导的长潜伏期戒断运动组成。这些退缩动作是由反复的刺激促成的，它被称为上弦。在stz诱导的糖尿病小鼠中，c -纤维介导的运动卷曲明显增强，而a - δ纤维介导的运动没有明显增强。少

The descending noradrenergic and serotonergic systems modulate the function of the spinal α-motoneurons which control movements of body and limbs. However, the function and changes in neuronal disease are unclear. In the present study, the following results were obtained.1. Serotonergic agonists have been shown both to increase and decrease spinal motor transmission. Motoneurons possess somatodendritic serotonin (5-HT)_2 receptors, which account for the increased excitability. However, it is unclear which receptor subtypes mediate the inhibitory effects on spinal reflexes. We showed that 5-HT_<1B> and 5-HT_<1D> receptors located in the spinal cord mediate the 5-HT-induced inhibition of spinal reflexes.2. Spinal reflexes and recurrent and presynaptic inhibitions in streptozotocin (STZ)-induced diabetic rats were examined. The recurrent inhibition which is mediated by glycine was depressed in diabetic rats. In addition, the inhibitory effect of 5-HT was decreased in those rats. These res … More ults show that the diabetogenic degeneration occurred in not only sensory but also motor systems.3. The relationships between ataxia and the monoamines concentrations of central nervous systems were examined in spinocerebellar atrophy (SCD) model mice. Two SCD model mice, rolling mouse Nagoya (RMN) and Ara-C mice which were produced by the administration of cytosine arabinoside on 2, 3, 4 days after birth, were used. The concentrations of monoamines were increased in CNS of these SCD model mice. The repeated administration of taltirelin hydrate, which is clinically used for SCD treatment, improved ataxia, but did not affect the monoamines concentration of CNS in RMN and Ara-C mice.4. We showed that the noxious stimuli-evoked flexor reflex of mice were composed from Aδ-fiber mediated short-latency and C-fiber-mediated long-latency withdrawal movements. These withdrawal movements are facilitated by repeated stimulation, it is called wind-up. In STZ-induced diabetic mice, the wind-up of C-fiber-mediated movement, but not Aδ-fiber-mediated one, was enhanced significantly. Less