Prediction of aggressiveness of prostate cancer using MR spectroscopy at ultra-high magnetic field

2003年，5例活检证实前列腺癌的患者被纳入本研究。采用3特斯拉磁共振单元获得磁共振图像和磁共振光谱。在5例患者中，有4例由于活检后前列腺出血导致光谱质量差而无法评估。需要消除直肠气体和前列腺出血以保持磁场均匀性。在2004年的研究中，在前列腺活检前进行MR检查，并在MR检查前一天使用泻药。51例患者中有25例（50%）获得高质量光谱。推测全前列腺射频激发不均匀是手术成功率低的原因之一。25例患者在光谱采集后计算（胆碱+肌酸）/柠檬酸盐峰面积比（CC/C）。外周带癌（PZ）的CC/C平均值为1.94，健康PZ的CC/C平均值为0.46 （p<0.0001）。在过渡区（TZ），癌症患者的平均CC/C为1.84，健康TZ患者的平均CC/C为1.03。本研究的局限性是检查成功率低，但成功射频激发患者的光谱质量优于1.5特斯拉的普通光谱。当射频激发方法得到彻底改进后，利用超高磁共振单元产生了非常重要的代谢物信息。

In 2003, 5 patients with biopsy proved prostate cancer were included in this study. MR images and MR spectra were obtained using 3 tesla MR unit. In 4 of 5 patients, spectra could not be evaluated because of poor quality due to post-biopsy prostate hemorrhage.Elimination of rectal gas and prostate hemorrhage was needed to keep magnetic field homogeneity. MR examination was performed before prostate biopsy, and using a purgative the day before the MR examination in 2004 study.High quality spectra were obtained in 25 of 51 patients (50%). It was presumed that one of the reasons of low successful rate was inhomogeneous radiofrequency (RF) excitation of whole prostate. In 25 patients, the (choline + creatine) / citrate peak area ratio (CC/C) was calculated after spectroscopic acquisition. The mean CC/C was 1.94 in peripheral zone (PZ) cancer, and 0.46 in healthy PZ (p<0.0001). In transition zone (TZ), the mean CC/C was 1.84 in cancer, and 1.03 in healthy TZ.The limitation of this study was low successful examination rate, but the spectral quality in patient with successful RF excitation was superior to usual spectrum at 1.5 tesla. When the RF excitation method is improved completely, significantly important metabolite information is produced using ultra-high MR unit.