Four channel console and sample changer for a 600 MHz NMR spectrometer

目前由波洪鲁尔大学化学与生物化学系RUBiospek|核磁共振服务部托管的600 MHz光谱仪的电子控制台自1998年以来一直在使用。但是，对这项技术的商业支持已经停止。因此，我们需要一个新的四通道核磁共振替代控制台，它将允许记录所有现代核磁共振实验，例如氘去耦和NUS实验的三重共振光谱。这将使医学相关蛋白及其复合物的结构、动态和功能研究成为可能，例如RASSF蛋白的小GTPase或SARAH结构域，以及金属肽生物偶联物，例如Octreotat或Enkephalin。另外，我们在此要求为600兆赫光谱仪提供一个温控换样器。这种样品转换器对于高通量的研究项目非常有益，比如nanocomac。在这个目前资助的联盟中，将共同努力开发针对革兰氏阴性菌引起的结核病等传染病的新型耐药抗生素。NanoComBac的概念与以前的方法有根本的不同，因为现在选择了双重甚至三重攻击策略，其中抗菌天然产物或其类似物与抗菌纳米载体分子相连接。

The current electronic console of the 600 MHz spectrometer hosted by the RUBiospek|NMR service department in the Faculty of Chemistry and Biochemistry at the Ruhr University Bochum has been in use since 1998. However, commercial support for this technology has been discontinued. Therefore, we request a new four-channel NMR replacement console, which will allow for the recording of all modern NMR experiments, such as triple resonance spectra with deuterium decoupling and NUS experiments, for example. These will enable structural, dynamic, and functional studies of medically-relevant proteins and their complexes, such as small GTPase or SARAH domains of RASSF proteins, as well as metal-peptide bioconjugates like Octreotat or Enkephalin, for instance. In addition, we hereby request a temperature-controlled sample changer for the 600 MHz spectrometer. This sample changer would be extremely beneficial for high-throughput research projects, such as NanoComBac. In this currently funded consortium, novel, resistance-breaking antibiotics against infectious diseases, e.g. tuberculosis, caused by gram-negative bacteria shall be developed in a joint effort. The NanoComBac concept differs fundamentally from previous approaches, as a dual or even triple attack strategy is now chosen, in which antibacterial natural products or their analogues are linked with antibacterial nanocarrier molecules.