Examination and execution of cancer research using virtual microscopy

组织芯片的研究于2006年7月在日本细胞计量学会学术会议上公布。之后，将各种参数尽可能有效地结合在一起，成功地提高了对除IV期以外的乳腺癌预后的判断。虚拟幻灯片系统提高了数据积累和比较的效率。基因组分析的癌症研究伴随着形态学的方法已经在我们的实验室进行。例如，我们分别报道了口腔鳞状细胞癌发生的两种不同的遗传途径，以及非肿瘤细胞中大规模基因组异常的积累。对少见类型涎腺癌进行了DNA芯片基因组分析和免疫组织化学基因表达分析的联合研究。此外，还证明了使用虚拟幻灯片，可以对远程地点之间的病理标本进行诊断会诊，并能够在30分钟内获得有效信息。利用虚拟幻灯片系统，通过互联网进行远程临床和病理会议。这个虚拟幻灯片系统也用于医学生教育。我们上传了包括组织学图像在内的病理培训指南的数字文件，医学生可以方便地下载、使用和修改。2007年3月，在日本病理学会的研讨会上，报告了虚拟幻灯片系统在教育、癌症研究或外科病理学中的应用。综上所述，虚拟幻灯片系统对癌症研究、教育和外科病理学都是有效的。

The research using tissue microarray was announced in the symposium of the Japan Cytometry Society in July, 2006.Afterwards, various parameters were combined as effectively as possible, and it succeeded in the improvement of judgment of the prognosis of breast cancers except stage IV. The virtual slide system improved the efficiency of the data accumulation and comparison. The genomic analysis of cancer research accompanied with morphological approaches has been performed in our laboratory. For example, we reported on two different genetic pathways for carcinogenesis of oral squamous cell carcinoma, and accumulations of large-sized genomic aberration in non-neoplastic cells as English paper, respectively. The combined study (genomic analysis using DNA-chip and gene expression analysis by immunohistochemical staining) in rare type of salivary gland cancer has been performed. Moreover, it was proven to use virtual slide, to execute the diagnostic consultation for pathological specimens between remote places, and to be able to obtain effective information within 30 minutes. Clinical and pathology conference using virtual slide system between remote places via internet were performed. This virtual slide system was used for medical student education, too. We uploaded digital files of guide for pathological training including the histological images, and it was able to be downloaded, used and modified easily by medical students. It reported on application of virtual slide system to education, cancer research, or surgical pathology in the workshop session of Japanese Society of Pathology in March, 2007. In conclusion, virtual slide system is effective for cancer research, education, and surgical pathology.