Development of prostate MR spectra analysis at high magnetic field for the purpose of evaluation of tumor aggressiveness

本研究纳入了80例前列腺癌患者。然而，我们可以比较29例患者的光谱数据和活检结果。（胆碱+肌酸）/柠檬酸盐（CC/C）的比例显着高于癌症比健康前列腺。CC/C比值与Gleason评分呈显著正相关（r=0.686）。高磁场下的CC/C比值可以预测肿瘤的侵袭性，基于密度矩阵的谱估计方法的发展使得测量体内柠檬酸盐的T2弛豫时间成为可能。为了了解频谱异常的位置和体积，开发了三维显示软件。该软件将提供选择治疗的重要信息。

80 patients with prostate cancer were included in this study. However, we could compare between spectra data and biopsy results in 29 patients. The (choline + creatine)/citrate (CC/C) ratio was significantly higher in cancer than in healthy prostate. CC/C ratio and Gleason score were correlated strongly (r=0.686). CC/C ratio at higher magnetic field may predict the tumor aggressiveness.Development of spectral estimation method based on density matrix made it possible to measure T2-relaxation time of in-vivo citrate. The three-dimensional display software was developed in order to understand the location and volume of spectral abnormalities. This software will offer the important information to select treatments.