Nutritional program using ^<13>C phenylalanine test in living donor liver transplantation

活体肝移植已被接受，并取得了良好的效果。然而，仍然存在“小尺寸移植物”的问题，有时会导致患者和移植物的生存率较低。关于肝移植对儿童氨基酸需求的影响，我们知之甚少。由于肝移植后血浆中支链氨基酸（BCAA）水平在芳香氨基酸水平正常的情况下下降，肝功能正常化可能无法完全纠正移植前BCAA代谢的变化。本研究的目的是利用13C苯丙氨酸试验确定肝移植后儿童的总BCAA需求。目的探讨13C苯丙氨酸检测在活体肝移植中的应用。

Liver transplantation from a living donor has been acceptted procedure with excellent results. However, there remain a problem 'small-for-size graft' which sometimes resulted in poor patient and graft survival.Little is known regarding the impact of liver transplantation on amino acid requirements in children. Since plasma levels of the branched-chain amino acids (BCAA) are decreased in the presence of normal levels of the aromatic amino acids after liver transplantation, normalization of hepatic function may not fully correct changes in BCAA metabolism that occur in the pretransplant period. The goal of the present study was to determine total BCAA requirements of children following liver transplantation using 13C phenylalanine test.We investigated 13C phenylalanine test in living donor liver transplantation program.