Modeling and simulation of pharmaco-mechanical fluid-structure interaction for an enhanced treatment of cardiovascular diseases

在这个项目中，我们的目标是强大的计算模型的耦合流体-结构相互作用的药理作用，以加强治疗心血管疾病。在未来，这可能会导致一个虚拟实验室，以帮助医生和病人在他们的决定。一个可以应用的例子是动脉粥样硬化;在这里，斑块破裂可能导致心脏病发作或中风。另一个重要的例子是马凡氏综合征患者的主动脉扩张，这是由于结缔组织的弱化，破裂导致致命的内出血。主要目标是开发一个强大的数值框架，包括合适的模型的计算模拟，使用高性能计算，药物对动脉壁中复杂的生化机械过程的影响。总体目标概括如下：一。为与药物诱导的平滑肌活化和组织组成重塑相关的复杂药物力学过程构建合适的模型。开发强大的数值耦合方案和求解器策略，为所产生的流体-结构-化学相互作用问题的预测模拟提供框架。通过调查合适的基准问题，将模拟结果与从我们的临床合作伙伴获得的测量数据进行比较，分析开发的方法。PI共同提供在该项目挑战所需的机械建模和数值方法界面上重叠的专业知识。本着优先计划SPP 2311的精神，通过包括临床合作伙伴的专业知识，该项目将力学，数学和医学学科联系起来。由此产生的计算和建模策略，该项目将直接适用于其他各种医学问题有关的药物机械相互作用。

In this project, we aim at the robust computational modeling of coupling fluid-structure interaction with pharmacological effects towards an enhanced treatment of cardiovascular diseases. In the future, this could lead to a virtual laboratory to assist medical doctors and patients in their decisions. An example, where this can be applied, are atherosclerotic arteries; here, plaque rupture may lead to a heart attack or a stroke. Another important example is the aortic dilation resulting from a weakening of connective tissues in patients with Marfan syndrome, where rupture results in fatal internal bleeding. The main goal is to develop a robust numerical framework including suitable models for the computational simulation, using high-performance computing, of the effects of drugs on the complex biochemo-mechanical processes in arterial walls. The overall goals are summarized as follows:I. To construct suitable models for the complex pharmaco-mechanical processes associated with drug-induced modifications of smooth muscle activation and remodeling of tissue composition.II. To develop robust numerical coupling schemes and solver strategies to provide a framework for the predictive simulation of resulting fluid-structure-chemistry interaction problems.III. To analyze the developed methods by investigating suitable benchmark problems, comparing simulation results with measurement data obtained from our clinical collaboration partners.Together, the PIs provide expertises which overlap at the interface of mechanical modeling and numerical methods required by the challenges of this project. In the spirit of the Priority Programme SPP 2311, by also including the expertise of clinical collaboration partners, this project bridges the disciplines of mechanics, mathematics, and medicine. The resulting computational and modeling strategies of this project will be directly applicable to various other medical problems related to a pharmaco-mechanical interaction.