Upgrade eines 3-Tesla-MRT-Scanners

我们要求升级我们的3T全身磁共振扫描仪。该扫描仪于2006年安装，将在不久的将来达到其生命周期的尽头。该扫描仪是CIMH创新精神病学和心理治疗研究翻译研究中心(ZIPP)的一部分。神经成像是ZI研究最重要的支柱之一，也是大多数多中心项目和合作的重要工具。CIMH的八个系或研究所和曼海姆医学院的两个系正在申请这次升级，并提供了大量的神经精神成像研究组合。我们的扫描仪也可供其他外部用户使用。使用条款在ZIPP的用户规则中进行了定义。Zipp安装的两台人体全身磁共振扫描仪用于科学神经成像研究，方法包括MRS、BOLD fMRI、DTI、ASL和形态测量。CIMH的科学家已经使用MR方法发表了400多篇同行评议的论文。一台扫描仪在2019年进行了升级。该计划是将剩余的第二个旧3T系统升级到当前最高水平的3T MR技术，使其与另一个升级的3T系统保持一致。这次升级在采集速度、分辨率提高、图像质量改善和长期稳定性方面的所有好处都对我们的研究特别有益。我们的研究得益于信噪比(SNR)的显著提高、更先进的fMRI和DTI协议、更短的扫描时间和更少的噪声。后者将特别有利于对儿童和精神病患者的计划研究。由于升级后的扫描仪性能优越，目前这款扫描仪的容量已达到极限，而旧扫描仪的使用率正在下降。这次升级不仅将提供最先进的图像和光谱质量，而且对我们的研究计划也至关重要，因为我们处理更大样本的工作需要高通量研究，而只有在扫描仪平台对准的情况下才能有效地执行这些研究。

We are requesting an upgrade for our 3T whole body MR scanner. The scanner was installed in 2006 and will reach the end of its life cycle in the near future. The scanner is part of the Translational Research Center for Innovative Psychiatry and Psychotherapy Research (ZIPP) within CIMH. Neuroimaging is one of the most important pillars of ZI research and an important tool in the majority of multicenter projects and collaborations. Eight departments or institutes of the CIMH and two departments of the Mannheim Medical Faculty are applying for this upgrade with a large portfolio of neuropsychiatric imaging studies. Our scanners are also accessible to other external users. The terms of use are defined in the ZIPP's user regulations. The two human whole-body MR scanners installed at ZIPP are used for scientific neuroimaging research with a variety of methods including MRS, BOLD fMRI, DTI, ASL, and morphological measurements. CIMH scientists have published over 400 peer-reviewed papers using MR methods. One scanner was upgraded in 2019. The plan is to upgrade the second remaining old 3T system to the highest level of current 3T MR technology, aligning it with the other upgraded 3T. All the benefits in terms of acquisition speed, increased resolution, improved image quality and long-term stability of this upgrade are of particular benefit to our research. Our research benefits from a significant increase in signal-to-noise ratio (SNR), more advanced fMRI and DTI protocols, shorter scan times, and less noise. The latter will especially benefit planned research on children and psychiatric patients. Due to the superior performance of the upgraded scanner, this scanner is currently at its capacity limit while occupancy rates of the old scanner are decreasing. The upgrade will not only provide state-of-theart image and spectral quality, but is also critical to our research program, as our work with larger samples requires high-throughput studies that can only be performed efficiently if the scanner platforms are aligned.