Molecular mechanism of immune regulation and immune tolerance

本项目分为三个小组：1)免疫调节的分子机制；2)免疫耐受的分子机制；3)免疫疾病的分子机制。三组相互配合，结果如下：通过研究TCR对HLA/肽复合物的识别以及与TCR相互作用诱导的细胞因子表达，阐明了免疫调节对天然抗原免疫应答的分子机制。通过在遗传水平上分析免疫功能障碍与疾病之间的关系，研究了与病理原因相关的广泛主题。此外，该项目还开发了几种转基因和基因敲除小鼠，如IL-2受体γ链突变小鼠、CD3缺陷小鼠、TCR-Tg小鼠以及Lyn激酶和HS1缺陷小鼠。在参与该项目的个别研究人员的合作下，还组织了几次国内专题讨论会、讲习班和国际专题讨论会。

This project was performed by three groups, 1) Molecular mechanisms of immune regulation ; 2) Molecular mechanisms of immune tolerance, and 3) Molecular mechanisms of immune diseases. These three groups cooperated with each other and the following results were obtained. Molecular mechanisms of immune regulation in immune response to natural antigens were elucidated by investigating the recognition of HLA/peptide complexes by TCRs and the resultant cytokine expression induced by interaction with the TCR.A wide range of subjects related to pathological causation were studied by analyzing the relationships between immune dysfunction and disease on a genetic level. Furthermore, several transgenic and gene knockout mouse such as the IL-2 receptor gamma chain mutant mice, CD3 deficient mouse, a TCR-Tg mouse, and the Lyn kinase and HS1 deficient mice were developed over the course of this project. Several domestic symposia, workshops and international symposia were also organized with the cooperation of individual researchers involved in this project.