Analysis on the thymic epithelial cells in the thymus from the rats which were irradiated

分别以6 Gy和8 Gy剂量照射大鼠。6 Gy照射后胸腺重量下降，在照射后2 ~ 3d内迅速恢复，8 Gy照射后胸腺重量恢复缓慢，在照射后7 ~ 11 d开始恢复。随后的回收率高达对照大鼠胸腺的65%。通过免疫组化和几种细胞因子的RT-PCR分析，对胸腺重量突变的机制进行了分析，表明细胞因子的变化与胸腺的恢复密切相关

Rats were irradiated at the dotes of 6Gy or 8Gy. Thymus weights reduced after irradiation and recovered rapidly within 2 to 3 days after irradiation in the case of 6Gy irradiation, while in the 8Gy irradiation thymus recovery were retarded and started to recover on day 7 to 11 after irradiation. Subsequent recovery was up to 65% of control rat thymus. The mechanisms responsible for abrupt thymus weight were analysed immunohistochemically and by RT-PCR analysis on several cytokines, suggesting cytokine changes were intimately related to the thymic recovery