To clarify the mechanism of Th1 suppression to protect renal function by angiotensin II receptor blocker

在各种慢性肾炎中，Th1/Th2平衡的改变对肾损害的发展至关重要。在系统性红斑狼疮（SLE）活动期的患者和模型小鼠中，Th1活性显著。我们将血管紧张素II型受体阻滞剂奥美沙坦10mg/kg/天给予9周的MRL/lps（自发狼疮）小鼠（n = 10） 19周。然后，我们检测了奥美沙坦给药或不给药小鼠MRL/lps小鼠脾脏培养T细胞上清中干扰素-γ (INF-γ)和白细胞介素-4 （IL-4）水平。结果显示，两组大鼠上清液中INF-γ和IL-4水平无明显差异。然而，给予奥美沙坦的MRL/lps小鼠比没有给予奥美沙坦的MRL/lps小鼠寿命更长。虽然奥美沙坦不抑制MRL/lps小鼠的Th1活性，但它可能对心脏等多种器官有有益作用。这种有益作用可能延长MRL/lps小鼠的寿命。

The change of Th1/Th2 balance is critical for the development of renal damage in various kind of chronic nephritis. Predominant Th1 activity is often seen in the patients and model mice with active stage of systemic lupus erythematosus (SLE). We gave angiotensin type II receptor blocker, olmesartan, 10mg/kg/day to MRL/lps (spontaneously manifesting lupus) mice (n = 10) aged 9 weeks for 19 weeks. Then, we checked Interferon-γ (INF-γ) and interleukin-4 (IL-4) levels in the supernatant of the cultured T cells from the spleen in mice MRL/lps mice with or without olmesartan administration. This revealed that there was no difference in INF-γ and IL-4 levels in the supernatants between the two groups. However, MRL/lps mice to which olmesartan was administered lived longer, than the MRL/lps mice to which olmesartan was not administered. Although olmesartan do not suppress the Th1 activity in MRL/lps mice, it may have a beneficial effect on various organs such as heart. This beneficial effect may elongate the life span of MRL/lps mice.