Immunological investigation for pathophysiology of infectious diseases induced by bacterial superantigens in neonates and childhood

1. 新生儿tss样疹性疾病（NTED）的临床表现我们在日本进行了一项全国性的NTED问卷调查。虽然每年患者总数减少，但足月新生儿NTED患者数量增加。msa引起的NTED病例也有所增加。我们分析了两个主要围产期中心共159例NTED患者的临床表现。我们分别在日本围产期和新生儿医学学会年会上和日本早产儿和新生儿医学学会年会上报道了这些结果。我们分析了在日本全地区收集的77例NTED患者血液中T细胞受体的变化。我们在日本儿科学会年会上报道了NTED的T细胞靶向标准。我们在儿科杂志上发表了一个超抗原诱导T细胞高反应的严重病例。我们观察到NTED患者IL-10产生的强烈反应。我们报告了美国围产期孕妇血清及其婴儿脐带血的抗体滴度。中毒性休克综合征（TSS）的分析我们观察了TSS和NTED之间T细胞反应的相似性和特殊差异。我们在2010年亚洲儿科研究学会大会上报道了这一结果。一例TSS患者表现出与NTED不同的T细胞反应，将发表在《儿科学》杂志上。川崎病分析我们分析了20例川崎病患者特异性T细胞的变化。我们无法确定超级抗原与川崎病之间关系的明确证据。我们观察到川崎病个体病例中细胞因子的产生有显著差异。

1. Clinical findings of Neonatal TSS-like exanthematous disease (NTED)We conducted a nation-wide questionnaire survey for NTED in Japan. Although total annual number of patients was decreased, the number of term neonatal patients with NTED was increased. The increase of NTED cases caused by MSSA was also reported. We analyzed clinical findings of total 159 NTED patients in the major two perinatal centers. We reported these results in Annual meetings of Japan Society of Perinatal and Neonatal Medicine and Japan Society for Premature and Neonatal Medicine, respectively.2. Immunological investigation of NTEDWe analyzed changes of T cell receptor in blood samples of 77 patients with NTED collected through whole area of Japan. We reported T cell targeted criterion for NTED in Annual Meeting of Japan Society for Pediatrics. We published a severe case with superantigen induced T cell high response in Pediatr Inf Dis J. We observed a particular strong response in IL-10 production in NTED patients. We reported antibody titer in pregnant women's sera and their infants' cord blood in Am J Perinatol.3. Analysis of Toxic shock syndrome (TSS)We observed both similarity and particular difference in T cell response between TSS and NTED. We reported the results in 1^<st> Congress of Asian Society for Pediatric Research. One case of TSS who showed the different T cell response from NTED will be published in Pediatr Int.4. Analysis of Kawasaki diseaseWe analyzed changes of specific T cell in 20 patients with Kawasaki disease. We could not identify a clear evidence of relation between superantigens and Kawasaki disease. We observed significant differences in production of cytokines between individual cases with Kawasaki disease.