Theoretical Study on Phase Space Landscapes Acquired by Evolution

以生态系统和蛋白质为研究对象，利用统计和计算物理的方法研究了演化组织相空间景观的特征，分析了生态系统的一般演化动力学模型。特别地，对于生态系统中的物种、细胞中的代谢物、蛋白质和mRNA的丰度分布，分析地获得了资源的生产力、成熟度和丰度的一些参数。研究了HIV病毒和人类免疫系统的进化动力学，得到了一些参数下无症状项的长度。对于蛋白质，我们研究了马达蛋白的自由能景观，得到了以下结果：（1）我们发现驱动蛋白和微管蛋白的大的结构波动都集中在功能重要的区域。特别是，我们的研究结果意味着微管，这是由微管蛋白和驱动蛋白的轨道的作用，是不只是一个轨道，但协同作用，在步进运动的驱动蛋白（论文提交）。(2)我们研究肌球蛋白的结构弛豫和核苷酸解结合的协同性。我们的研究结果表明，核苷酸的结合和解结合改变了自由能景观的结构（提交了一篇论文）。

Mainly for ecosystems and proteins, characteristics of the evolutionarily-organized phase-space landscapes are studied using statistical and computational physics.For ecosystems, general evolutionary dynamics models are analyzed. In special, abundance distributions, e.g. for species in ecosystem, metabolites in cells, proteins and mRNA, is analytically obtained for some parameters of productivity, maturity and abundance of resources. Evolutionary dynamics of HIV virus and human immune system is also studied and the length of the asymptomatic term is obtained for some parameters.For proteins, we studied free-energy landscape of motor proteins and obtained the following results: (1)We found that large structural fluctuations of kinesin and tubulin are localized at functionally important regions. In particular, our results imply that the microtuble, which is composed of tubulin and plays a role of rail for kinesin, is not just a rail but acts cooperatively in stepping motion of kinesin (papers were submitted). (2) We investigate cooperativity of structural relaxation and nucleotide unbinding of myosin. Our results imply that the binding and unbinding of nucleotide switches the the structures of free-energy landscape (a paper was submitted).On the above resuls, five papers have been appeard on international journals listed in 11.REFERENCES.