Control of intraocular neovascularization by vitreous remodeling

透明细胞通过产生细胞外基质(ECM)参与玻璃体重塑。因此，我们认为玻璃体细胞在玻璃体视网膜病变中起着重要作用。为了验证我们的假设，我们建立了新的猪玻璃体透明细胞系。在糖尿病视网膜病变、增殖性玻璃体视网膜病变等各种疾病中，玻璃体中细胞因子的浓度发生了变化。这一变化会影响肺透明细胞。因此，我们通过刺激各种细胞因子来检测细胞外基质产生的变化。此外，我们还研究了添加类固醇对细胞外基质产生的调节。

Hyalocyte is concerned with vitreous remodeling by producing extracellular matrix (ECM). So we suppose hyalocyte plays an important role in vitreo-retinal disorders. To prove our hypothesis, we have established new cell-line of hyalocyte from pig vitreous.The concentration of cytokines in the vitreous is changed in various disorders such as diabetic retinopathy, proliferative vitreo retinopathy. This change affects for hyalocyte. So we have examined the change of ECM production by stimulating various cytokines. Also we have studied about regulation of ECM production by adding steroid.