Clinical nuclear madicine by using small high resolution gamma camera in head and neck region

用于放射引导手术的小型半导体伽马相机(临床型和试验型)提供了比传统闪烁相机(CSC)更好的能量分辨率。用直径1 mm的聚乙烯管制成的20 mm高的“S”人物体模，填充30MBq的~(99)Tc，直接放置在每个相机的表面上，采集时间为2-S。临床型和试验型获得的图像比CSC清晰得多，因此临床型和试验型获得了高灵敏度和高空间分辨率。临床类型的表现与试验类型相似。在机构审查委员会批准研究方案并获得所有患者的知情同意后，进行了初步的临床研究。头颈部疾病127例(恶性肿瘤72例，良性肿瘤4例，涎腺疾病6例，涎石5例，口干症7例，干燥综合征4例，骨眼…10例多发唇炎，其中7例为颞下颌关节病，11例为其他疾病)，其中93例行放射性核素扫描，25例行唾液腺扫描，9例行淋巴扫描。初步临床研究成功地利用伽马相机在短时间内进行了成像。伽马相机提供了比传统闪烁相机更好的图像。S 15、30和60次拍摄伽马相机图像，30和60次S伽马相机图像清晰地显示乳腺癌(由滨松大学医学部和庆应大学医学部)、食道癌(庆应大学医学部)、喉癌(庆应大学医学部)、牙周癌(日本牙科大学)、舌癌(日本牙科大学)和棘细胞癌(新泻癌症中心医院)患者的淋巴结。在国际临床试验研究中，15岁和30岁的S分别拍摄了伽马相机的图像，30-S的伽玛相机的图像清楚地显示了患者的淋巴结(由美国约翰·韦恩癌症研究所提供)。伽玛相机在分离前哨淋巴结以进行活检方面可能比目前的技术更具优势。这种相机的另一个潜在应用是诊断，特别是位于甲状腺、颌面部骨骼和关节等组织或器官中的小而浅的病变。较少

Small semiconductor gamma cameras(clinical type and trial type) for radioguided surgery provided better energy resolution than a conventional scintillation camera (CSC). Images obtained form a 20-mm-tall "S" figure phantom made from a 1-mm-diameter polyethylene tube and filled with 30MBq Tc-99m, that was placed directly on the surfacee of each camera with a 2-s acquisition time. The images obtained by clinical type and trial type were much clearer than that obtained with a CSC, and so clinical type and trial type achieve high sensitiveity and high spatial resolution. clinical type's performance is similar equal to trial type's it.Preliminary clinical studies were performed, after institutional review boards approved the study protocol and informed consent was obtained from all patients. 127 patients with head and neck diseases (72 with malignant tumor, 4 with benign tumors, 6 with diseases of salivary gland, 5 with sialolith, 7 with xerostomia, 4 with sjogren syndrome, 10 with osteomye … More litis, 7 with arthrosis of temporomandibular joint and 11 with another diseases) underwent scintigraphy using the gamma camera and the CSC (bone scintigraphy were performed in 93 patients, salivary gland scintigraphy were performed in 25 patiens and lymph scintigraphy were performed in 9 patiens). Preliminary clinical studies were successful in imaging in short acquisition time by using the gamma cameras. Gamma cameras provided better images than conventional scintillation camera. Gamma cameras images were taken for 15, 30 and 60 s, 30- and 60-s gamma cameras images clearly showed lymph nodes of patients who had breast cancer (by Hamamatsu University School of Medicine and Keio University School of Medicine), Esophageal cancer (by Keio University School of Medicine), laryngeal cancer (by Keio University School of Medicine), carcinoma of gingival (The Nippon Dental University), carcinoma of tongue (The Nippon Dental University) and prickle cell carcinoma (Niigata Cancer center Hospital) could be clearly visualized by the gamma cameras. In the International Clinical Trial study, Gamma camera's images were taken for 15 and 30 s, 30-s gamma camera's images showed clearly lymph nodes of patients (by John Wayne Cancer Institute, USA). The Gamma camera may offer advantage over current techniques for isolating sentinel lymph nodes for biopsy. A further potential application for this camera is in diagnosis, particularly of small, superficiall lesions situated in tissues or organs such as the thyroid gland, jaws facial bones and joints. Less