Dynamik in und mit mesoporösen Nanostrukturen (B06+)

在这个项目中，我们研究分子的动力学在介孔结构的背景下。在第一部分，我们将开发新的介孔通道结构，并研究生物活性客体分子的物理和化学动力学。第二部分是介孔纳米载体体系。在这里，我们将利用多种选择来功能化我们迄今为止建立的介孔二氧化硅纳米颗粒，并研究它们与活细胞相互作用的动力学。此外，我们将为光诱导细胞内生物活性分子的同步释放和控制细胞内信号级联发展新的概念。

In this project we study the dynamics of molecules in the context of mesoporous structures. In the first part we will develop new mesoporous channel structures and study the physical and chemical dynamics of biologically active guest molecules. The second part deals with mesoporous nanocarrier systems. Here, we will take advantage of the multitude of options to functionalize mesoporous silica nanoparticles we have established so far and study the dynamics of their interactions with living cells. In addition we will develop new concepts for the light-induced synchronized release of bioactive molecules in cells and for controlling intracellular signaling cascades.