Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging

探测器技术的进步导致了小动物成像系统的开发和商业化，例如microPET，其提供活体动物中放射性化合物的高分辨率图像，但图像只能定性解释。我们的目标是为这些新的成像系统开发定量技术。主要成果将包括测量和校正由于体内光子相互作用引起的信号损失的新方法和集成图像重建算法。这将导致新一代的定量成像设备;新技术将直接转化为临床成像系统，并将扩大microPET在生命科学中的应用范围。

Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and correcting for signal loss due to photon interactions in the body and integrated image reconstruction algorithms. This will lead to a new generation of quantitative imaging devices; the new technologies will be directly translatable to clinical imaging systems and will broaden the range of microPET applications in the life sciences.