Fetal MagnetoEncephaloGraphy with OPM

在Inserm 1105和Tubingen的fMEG中心，分别开发了早产儿高分辨率脑电图（HR-EEG）和胎儿脑磁图（MEG），提供了从妊娠最后三个月到子宫内和子宫外未成熟网络的能力。我们将用类似的协议来分析神经网络的早期发展。亚胺和图宾根的自发活动和诱发的大脑对刺激的反应将通过两种方法在子宫内和子宫外进行分析。我们将开发(1)MEG和HR-EEG中诱发反应的通用范式。(2)健康早产儿和同胎龄胎儿的fMEG和HR-EEG同时记录。(3)从早期HR-EEG到fMEG的动态估计器模型。(4)利用CEA围绕光泵磁强计（OPM）开发的新方法，使任务适应胎儿和早产儿在亚眠进行的记录。亚眠早产儿的HR-EEG，图宾根的fMEG， CEA的OPM的开发，这些互补的技能是项目成功的保证。

High-resolution EEG (HR-EEG) in preterms and magnetoencephalography(MEG) in foetuses (fMEG) have been developed in Inserm 1105 and in the fMEG center in Tubingen, respectively, providing access to the abilities of the immature network from the last trimester of gestation in and ex utero. We will analyze with similar protocols the early development of the neuronal networks. Both spontaneous activity and evoked cerebral responses to stimuli will be analysed by both approaches in and ex utero in Amiens and Tubingen. We will develop (1) common paradigms for evoked responses in MEG and HR-EEG. (2) concurrent fMEG and HR-EEG, recordings in healthy prematures and foetuses of the same Gestational Age (GA). (3) a dynamic estimator model from HR-EEG in premature to fMEG and vice versa. (4) adapt the tasks to the recordings performed in Amiens in foetuses and preterms with the new approach developed around the optically pumped magnetometer (OPM) by the CEA. The complementary skills, HR-EEG in preterms in Amiens, fMEG in Tubingen and development of OPM in CEA, is a guarantee of success for this project.