Synthesis and Preparation of Smart Membrane

为了开发具有高性能分子腔的新型智能膜，我们指定、合成并制备了一些聚合物膜。主要研究结果如下：(1)制备了DNA偶联的纤维素膜。较大孔径的膜具有较好的L氨基酸通透性，而较小孔径的膜具有较好的D型氨基酸通透性。此外，在壳聚糖膜中引入铂配合物增加了DNA的含量，同时也显示出L式氨基酸的优先透过性，这是通道型的膜和光学分辨膜以及细胞膜。另一方面，引入羧酸基团的聚氨酯泡沫(PU)膜可以得到良好的细胞精细化膜，造血细胞的回收率达到75%，特别是透明质酸表面修饰的PU膜对细胞有很高的分离度(2…)。此外，通过“自组装法”可以实现单体和/或低聚物的可控分层，成功地制备了分子链沿膜厚方向排列的微细膜。可以建立使分子腔沿膜厚方向规则排列的技术。一方面，对用丁烷磺化聚苯并咪唑修饰的新型质子传输膜中水的团簇结构进行了分析，水分子分散到了整个膜中。(3)为了开发具有良好分子腔设计的高性能分离膜，与C基团协作，对分子结构进行了计算机模拟和设计，并尝试了环酰亚胺类化合物的合成。成功地制备了环酰亚胺与部分聚合物的复合膜。用四聚环酰亚胺、苯得到的复合膜选择性地分离苯。结构分析由B组合作完成。

To develop the novel smart membranes with high performance molecular cavities, some polymeric membranes are designated, synthesized, and prepared. The results below summary were obtained.(1) The cellulose-based membranes conjugated with DNAs were prepared. The membrane with large pore diameter showed preferential permeability of L-type amino acid, in contrast to case of small diameter membrane showing that of D-Type one. Furthermore, the introduction platinum complex to the chitosan membrane increases the amounts of DNA, and exhibited also preferential permeability of L-type amino acid In conclusion, these were channel type and optical resolution membranes as well as the cell membranes On the other hand, the polyurethane foam (PU) membranes introduced carboxylic acid groups were prepared to get a good cell-refinement membranes, the recovery factor of hematogenous cells was reached to 75% Especially, the surface-modified PU membrane with hyaluronic acid was highly separated the cells.(2 … More ) Monomer and/or the oligomer could be controllably layered by the "self-assembly method", it succeeded in manufacturing the fine membrane where molecular chains were arrangement to film thickness direction. The technique which makes the molecular cavities arranged regularly to film thickness direction could be established. On the one hand, the results of analyzing the cluster structure of the water in the new-created membrane for the proton transport, which was modified with the butane sulfonated polybenzoimidazole, the water molecule dispersed to the whole membrane.(3) In order to develop the high-performance separation-membrane having well-designed molecular cavities with collaboration of Group C, the molecular structures were simulated and designed by computer simulations, and the synthesis of cyclo-imide compounds was attempted. It succeeded in production of the composite membrane of cyclo-imides and the some polymers. The composite membrane obtained with the tetramer cyclo-imides, benzene was separated selectively. The structural analyses were performed by cooperation of Group B. Less