Development of an information-intensive basis for cancer chemotherapy
Development of an information-intensive basis for cancer chemotherapy
批准号:
17012025
负责人:
YAMORI Takao
金额:
$159.36万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
为了支持有新化合物的研究人员,我们用我们的筛选系统评估了他们的化合物(~1000)的生物活性,并提供了结果。大多数研究结果都是在他们同意的情况下发表的。我们开发了“SCADS抑制剂试剂盒”,包含300种已知作用机制的化合物,并将其分发给申请人,以鼓励他们进行化学生物学研究。我们开发了另一个由研究人员储存的200种新化合物库,并将其分发给申请人。我们收集了新的分子靶向抗癌药物的信息,并通过网页提供。
英文摘要
To support researchers who have new compounds, we evaluated biological activities of their compounds (~1000) by our screening system and provided them the results. Most of the results were published with their consent. We developed "SCADS inhibitor kit", a library including 300 compounds with known mechanisms of action, and distributed it to applicants to encourage their chemical biology studies. We developed another library of 200 new compounds deposited by researchers and distributed it to applicants. We collected information on new molecular targeted anticancer drugs and provided it via web pages.
期刊论文(172)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1073/pnas.0902150106
发表时间:
2009-09-22
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Sasaki, Kazuki, Ito, Tamaki, Yoshida, Minoru]
通讯作者:
Yoshida, Minoru
DOI:
10.1248/bpb.33.168
发表时间:
2010-02-01
期刊:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子:
2
作者:
[Fukazawa, Hidesuke, Ikeda, Yoshimi, Uehara, Yoshimasa]
通讯作者:
Uehara, Yoshimasa
Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.
通过衣霉素框架中的芳环移位进行组蛋白脱乙酰酶抑制剂的分子设计。
DOI:
--
发表时间:
2007
期刊:
Bioorg. Med. Chem. 15
影响因子:
--
作者:
[Shivashimpi, G. M. Amagai, S. Kato, T. Nishino, N. Maeda, S. Nishino, T. G. and Yoshida. M.]
通讯作者:
T. G. and Yoshida. M.
Involvement of PP2A nuclear accumulation and subsequent inactivation of AP-1 in leptomycin B-inhibited cyclin D1 expression.
PP2A 核积累和随后的 AP-1 失活参与了瘦霉素 B 抑制细胞周期蛋白 D1 的表达。
DOI:
--
发表时间:
2007
期刊:
Oncogene 26
影响因子:
--
作者:
[Tsuchiya, A. Tashiro, E. Yoshida, M. and Imoto, M.]
通讯作者:
M.
Common Peak Approach Using Mass Spectrometry Data Sets for Predicting the Effects of Anticancer Drugs on Breast Cancer.
使用质谱数据集的共峰方法预测抗癌药物对乳腺癌的影响。
DOI:
--
发表时间:
2007
期刊:
Cancer Informatics. 3
影响因子:
--
作者:
[Ushijima, M. Miyata, S. Eguchi, S. Kawakita, M. Yoshimoto, M. Iwase, T. Akiyama, F. Sakamoto, G. Nagasaki, K. Miki, Y. Noda, T. Hoshikawa, Y and Matsuura. M.]
通讯作者:
Y and Matsuura. M.
共 161 条
Discovery of innovative molecular targeted drugs based on Cancer Cell Informatics
-
批准号:22240092
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$32.28万
-
财政年份:2010
-
负责人:YAMORI Takao
-
依托单位:
Development and Application of"Cancer Cell lnformatics" for identifying novel drug seeds
-
批准号:17390032
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.18万
-
财政年份:2005
-
负责人:YAMORI Takao
-
依托单位:
Analysis of biomarker proteins for chemosensitivity by protein chip
-
批准号:14370760
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.62万
-
财政年份:2002
-
负责人:YAMORI Takao
-
依托单位:
海外基金