Comparative analysis of large scale genome data and knowledge discovery

我们通过比较生物序列，如DNA、RNA和氨基酸序列，积累了大量与分子生物学有关的知识。另一方面，测序技术的快速发展也带来了大量序列数据的积累。那么，它的数量现在已经超过了现有序列比较法的应用上限。在这里，我们开发了能够高精度比较如此大量的序列数据的方法，并通过应用这些方法解决了生物知识发现的挑战。因此，我们揭示了microRNA功能转录调控的分子机制。

We have accumulated a large amount of knowledge concerning with molecular biology by comparing biological sequences, such as DNA, RNA and amino acid sequences. On the other hand, rapid progress of sequencing technology have brought accumulation of a large amount of sequence data. Then, its quantity is now exceeding the upper limit of application of existing sequence comparison methods. Here, we have developed methods which are capable of comparing such a large amount of sequence data with high accuracy, and have tackled the challenge to biological knowledge discovery by applying the methods. As a result, we have revealed molecular mechanism of transcriptional regulation of microRNA function.