Higher sensory processing mechanisms investigated by transcranial imaging of mouse cortical activities

来自线粒体的内源性绿色荧光信号反映了脑代谢的活性依赖性变化，并可用于脑功能成像。小鼠内源性黄素蛋白荧光成像特别重要，因为小鼠透明的头骨允许皮质活动的经颅荧光成像。使用这种技术，我们调查了小鼠的躯体感觉，视觉和听觉皮层的皮层活动和经验依赖的可塑性。

Endogenous green fluorescence signals derived from mitochondria reflect activity-dependent changes in brain metabolism, and may be exploited in functional brain imaging. Endogenous flavoprotein fluorescence imaging in mice is especially important because the transparent skull of mice allows transcranial fluorescence imaging of cortical activities. Using this technique, we investigated cortical activities and experiencedependent plasticity in the somatosensory, visual and auditory cortices of mice.