Elucidation of molecular pathomechanisms of schizophrenia

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To clarify the molecular basis of schizophrenia, we have explored and detected the developmentally regulated schizophrenomimetic-inducible genes from the rat brain regions as thenovel candidates for schizophrenia-associated molecules in terms of the phenomena that schizophrenia and its pharmacological models usually occur after the specific postnatal period.Moreover, we have newly cloned and clarified the two genes and the glial regulation, respectively,which are closely related to the endogenous D-serine signal controls to get further cues for theinvestigation on the possible dysfunction of the NMDA type glutamate receptor and its co-agonistD-serine in the schizophrenia brains.