Insights into lipopolysaccharide (LPS) transport by solid-state NMR spectroscopy (P01)

脂多糖(LPS)是革兰氏阴性菌不对称外膜的主要成分，对抗生素和哺乳动物免疫系统具有保护作用。维持这种不对称性的一个重要步骤是ABC Floppase MSBA将核心-内毒素转移到内膜，内毒素通过脂多糖运输系统(LPT)从这里向外膜转移。在P01项目中，我们将探讨脂多糖的转运机制，并通过固体核磁共振研究它的存在如何改变膜的性质。

Lipopolysaccharides (LPS) are the main component of the asymmetric outer membrane of Gram-negative bacteria and protect them against antibiotics and the mammalian immune system. One essential step in maintaining this asymmetry is the translocation of core-LPS across the inner membrane by the ABC floppase MsbA from where LPS is carried on towards the outer membrane by the lipopolysaccharide transport (LPT) system. In project P01, we will address the LPS transport mechanism and explore how its presence alters membrane properties by solid-state NMR.